The study of microglial cells has recently gained importance for those researching degeneration and regeneration. Microglia in the regenerating and degenerating CNS supports the assertion that understanding microglial biology could perhaps be pivotal for unraveling the pathogenetic mechanisms that underlie Alzheimer's disease, In addition, microglia are also critical for understanding the sequelae of traumatic brain and spinal cord injury, and for the important post-traumatic repair processes. This book gives an up to date account of the role of microglia in degeneration and regeneration of the nervous system and reviews their cell function and physiology.
Foreword Section I. Microglial Physiology Physiology and Pathophysiology of Microglial Cell Function by Wolfgang J. Streit Roles of Microglia in the Developing Visual System by Julio Navascues, Miguel A. Cuadros, Ruth Calvente, Jose L. Marin-Teva Microglial Ion Channels by Claudia Eder Calcium Signaling in Microglial Cells by Thomas Muller Microglia as a Source and Target of Cytokine Activities in the Brain by Uwe-Karsten Hanisch Section II. Acute CNS Injury and Repair Microglia and Macrophage Responses in Cerebral Ischemia by Guido Stoll, Sebastian Jander, Michael Schroeter Role of Microglia and Macrophages in Secondary Injury of the Traumatized Spinal Cord: Troublemakers or Scapegoats? by Phillip G. Popovich Microglial Response in the Axotomized Facial Motor Nucleus by Gennadij Raivich Neuroprotective Roles of Microglia in the Central Nervous System by Kazuyuki Nakajima, Shinichi Kohsaka Influences of Activated Microglia/Brain Macrophages on Spinal Cord Injury and Regeneration by Alexander G. Rabchevsky Opportunities for Axon Repair in the CNS: Use of Microglia and Biopolymer Compositions by Joshua B. Stopek, Wolfgang J. Streit, Eugene P. Goldberg Section III. Alzheimer's Disease and Aging Beta Amyloid Protein Clearance and Microglial Activiation by Sally A. Frautschy, Greg M. Cole, March D. Ard Microglia and Aging in the Brain by Caleb E. Finch, Todd E. Morgan, Irina Rozovsky, Zhong Xie, Richard Weindruch, Tomas Prolla Index