Preface. David.W. McCandless.- 1. Functional Anatomy of the Brain. John M. DeSesso.- 2. Brain Metabolic Adaptations to Hypoxia. Michelle A. Puchowicz, Smruta S. Koppaka, and Joseph C. LaManna.- 3. Hypoglycemic Brain Damage.- Roland N. Auer.- 4. Experimental Ischemia: Summary of Metabolic Encephalopathy. W. David Lust, Jennifer Zechel, and Svetlana Pundik.- 5. Stroke-Clinical Features. Svetlana Pundik, and Jose I. Suarez.- 6. The Role of Animal Models in the Study of Epileptogenesis. Kate Chandler, Pi-Shan Chang, and Matthew Walker.- 7. Seizure-Induced Neuronal Plasticity and Metabolic Effects. Monisha Goyal.- 8. Metabolic Encephalopathies in Children. Joseph DiCarlo.- 9. Pathophysiology of Hepatic Encephalopathy: Studies in Animal Models. Roger F. Butterworth.- 10. Hepatic Encephalopathy. Karin Weissenborn.- 11. Uremic and Dialysis Encephalopathies. Allen I. Arieff.- 12. Thiamine Deficiency: A Model of Metabolic Encephalopathy and of Selective Neuronal Vulnerability. Saravanan Karuppagounder and Gary E. Gibson.- 13. Alcohol, Apoptosis, and Oxidative Stress. George I Henderson, Jennifer Stewart, and Steven Schenker.- 14. Wernicke's Encephalopathy. Maryam R. Kashi, George I Henderson, and Steven Schenker.- 15. The Genetics of Myelination in Metabolic Brain Disease: The Leukodystrophies. John W. Rumsey.- 16. Bilirubin Encephalopathy. Jeffrey W. McCandless and David W McCandless.- 17. Infectious And Inflammatory Metabolic Encephalopathies: Concepts in Pathogenesis. Kottil Rammohan.- 18. Major Depression and Metabolic Encephalopathy: Syndromes More Alike Than Not? Brian H. Harvey.- 19. Attention-deficit/hyperactivity Disorder as a Metabolic Encephalopathy. Vivienne Ann Russell.- 20. Brain Damage in Phenylalanine, Homocysteine, and Galactose Metabolic Disorders. Kleopatra H.Schulpis and Stylianos Tsakiris.- 21. Wilson Disease. Peter Ferenci.- 22. Metabolic Abnormalities in Alzheimer Disease. Florian M. Gebhardt and Peter R Dodd.- 23. Prions and the Transmissible Spongiform Encephalopathies. Richard C. Wiggins.- 24. Lead Encephalopathy. Ivan J. Boyer.- Index.
Metabolic Encephalopathy is meant to combine and correlate animal and human studies. It is hoped that increased awareness of the importance of early diagnosis and treatment of these disorders may result in a lowering of the incidence of structural changes and morbidity. These disorders hold a special fascination for both basic scientists and clinical investigators because they are accessible, treatable and there exists good animal models for study. Therefore, this book will pull together basic and clinical neuroscience issue in the treatment of specific metabolic encephalopathies.
Considers both animal and human studies, and integrates them into statements of mechanisms and biochemical alterations and treatments
Contains the most commonly seen metabolic encephalopathies and those in which the diagnosis and treatment have advanced and benefited from technological studies
Will be of interest to both researchers and clinicians