Covering one of the hottest topics in immunology today, this book provides a comprehensive view of all types of regulatory T cells described so far in the literature. The book will have broad appeal to both researchers and clinicians.
A major process of rediscovery has taken place in the field of Cellular Immunology over the past 12 years-subsets of T lymphocytes exist that are specifically dedicated to regulation or as it should be more appropriately termed suppression of all aspects of immune responses.
It was only after Prof. Sakaguchi identified the CD25 antigen in 1995 as a marker for a major population of T cells that had suppressor functions both in vitro and in vivo that the resurgence in the regulatory T cell area could begin.
The regulatory T cells field has grown dramatically over the past decade. It is now impossible to read a journal that does not contain numerous papers whose titles deal with regulatory T cells. More importantly, it is also difficult to submit a new research grant proposal in any area of immunologic research that does not include a section on analysis on the contribution of regulatory T cells to the subject matter under study.
Regulatory T cells can be best thought of today as "teenagers" ready to take on all the challenges of complex immune responses. In ten years, the field will certainly be more mature, and manipulation of regulatory T cell function by cellular biotherapy, antibodies and small molecules will be routine function of the clinical immunologist.
- From Preface by Prof. Ethan Shevach, National Institute of Health, USA
It has been for long debated whether suppressor/regulatory T cells did actually even exist. Today, this question is no longer accurate and the subject of regulatory T cells is the object of a constantly growing interest in immunologists and clinicians. There is no doubt that the history of Tregs will make a new big leap ahead.
- From Chapter One by Prof. Shimon Sakaguchi, Kyoto University, Japan
Preface by Ethan M. Shevach, National Institute of Health, USA.- Part One: Immunobiology of Regulatory T Cells.- Regulatory T cells and the control of auto-immunity: from day 3 thymectomy to FoxP3+ regulatory T cells by Makoto Miyara and Shimon Sakaguchi, Kyoto University, Japan.- FoxP3 and regulatory T cells by Karsten Kretschmer, Irina Apostolou, Panos Verginis and Harald von Boehmer, Harvard University.- Thymic and peripheral generation of CD4+CD25+FoxP3+ regulatory T cells by Paola Romagnoli, Julie Ribot, Julie Tellier and Joost P.M. van Meerwij, INSERM, France.- The role of IL-2 in the development and peripheral homeostasis of naturally occurring CD4+CD25+Foxp3+ regulatory T cells by Allison L. Bayer and Thomas R. Malek, University of Miami, USA.- IL-2 signaling and CD4+CD25+ regulatory T cells by Louise M. D'Cruz and Ludger Klein, University of Vienna, Austria.- TGF-b and regulatory T cells by Yisong Y. Wan and Richard Flavell, Yale University, USA.- TGF-b controls reciprocal differentiation of CD4+CD25+FoxP3+ regulatory T cells and IL-17 producing Th17 cells from naïve CD4+CD25- T cells by Wanjun Chen, National Institute of Health, USA.- Molecular signalling in regulatory T cells (by Natasha R. Locke, Natasha K. Crellin and Megan K. Levings, University of British Columbia, Canada.- Part Two: Regulatory T Cells in Disease and Clinical Application.- CD4+FoxP3+ regulatory T cells in immune tolerance by Ciriaco A. Piccirillo, McGill University, Canada.- Regulatory T cell control of autoimmune diabetes and their potential therapeutic application by Qizhi Tang and Jeffrey A. Bluestone, University of California at San Francisco, USA.- CD4+CD25+ regulatory T cells as adoptive cell therapy for autoimmune disease andfor the treatment of graft-versus-host disease by Swati Acharya and C. Garrison Fathman, Stanford University, USA.- Natural CD4+CD25+ regulatory T cells in regulation of autoimmune disease by Adam P. Kohm and Stephen D. Miller, Northwestern University, USA.- Multiple sclerosis and regulatory T cells by Jonathon Hutton, Clare Baecher-Allan and David A. Hafler, Harvard University, USA.- CD4+CD25+ regulatory T cells and TGF-b in mucosal inflammation by M. Fantini and Markus F. Neurath, University of Mainz, Germany.- Induction of adaptive CD4+CD25+FoxP3+ Regulatory T cell response for autoimmune disease by Jian Hong, Sheri Skinner and Jingwu Zhang, Shanghai Institutes of Biological Sciences, China.- Regulatory T cells in transplantation by Kathryn J Wood, Andrew Bushell, Manuela Carvalho-Gaspar, Gang Feng, Ross Francis, Nick Jones, Elaine Long, Shiqiao Luo, Ian Lyons, Satish Nadig, Birgit Sawitzki, Gregor Warnecke, Bin Wei and Joanna Wieckiewicz, University of Oxford, the UK.- Regulatory T-cells in therapeutic transplantation tolerance by Herman Waldmann, Elizabeth Adams, Paul Fairchild and Stephen Cobbold, University of Oxford, the UK.- CD4+CD25+ regulatory T cell therapy for the induction of clinical transplantation tolerance by David S. Game, Robert I. Lechler and Shuiping Jiang, King's College London, the UK.- Regulatory T cells in allergic disease by Catherine Hawrylowicz, King's College London, the UK.- Regulatory T cells and tumour immunotherapy by Ilona Kryczek and Weiping. Zou, University of Michigan, USA.- Regulatory T cells in hepatitis and hepatocellular carcinoma by Fu-Sheng Wang and George F. Gao, Beijing Institute of Infectious Diseases, China.- CD4+CD25+ regulatory T cells in viral infections by Wayne A. Tompkins, Mary B. Tompkins, Angela M. Mexas and Jonathan E. Fogle, North Caro
A major process of rediscovery has taken place in the eld of Cellular Immunology over the past 12 years-subsets of T lymphocytes exist that are speci cally d- icated to regulation or as it should be more appropriately termed suppression of all aspects of immune responses. It is certainly appropriate at this time to recall some of the history that lead to the development of the concept of immune r- ulation/suppression. Shortly after the term helper T cells was coined to described lymphocytes that "helped" both humoral and cell-mediated responses, studies from thelaboratoryofthe lateProfessorRichardGershondemonstratedthatundercertain conditions, antigen recognition by T lymphocytes also resulted in the development of cells that are able to suppress immune responses. Unfortunately, research in this eld rapidly shifted from studies of the function of the suppressor T cells to studies of their soluble products that were thought to be shed or secreted T cell receptors. A number of highly complex suppressor cell pathways and cell circuits were dev- opedand werethe subjectsof morethan5,000papersduringthisera. In 1983-1984, this eld completelycollapsed as studies called into question the existence of the I-J region of the mouse major histocompatibility complex that was thought to encode one of the major chains of the suppressor T cell factors.
Covers one of the hottest topics in immunology today
Compiles recent developments in T cell immunobiology and clinical applications
Will have broad appeal to both researchers and clinicians