Arsenite Resistance in Leishmania and Possible Drug Targets.- Unique Characteristics of the Kinetoplast DNA Replication Machinery Provide Potential Drug Targets in Trypanosomatids.- Drugs and Transporters in Kinetoplastid Protozoa.- Selective Lead Compounds against Kinetoplastid Tubulin.- Fishing for Anti-Leishmania Drugs: Principles and Problems.- Sterol 14-Demethylase Inhibitors for Trypanosoma cruzi Infections.- Histone Deacetylases.- Targeting Glycoproteins or Glycolipids and Their Metabolic Pathways for Antiparasite Therapy.- DNA Topoisomerases of Leishmania: The Potential Targets for Anti-Leishmanial Therapy.- Antiparasitic Chemotherapy:.- Searching the Tritryp Genomes for Drug Targets.- Purine and Pyrimidine Metabolism in Leishmania.
The dreaded protozoal diseases caused by a number of Kinetoplastid parasites threaten mankind, as therapeutic tools for the treatment of most parasitic diseases are extremely limited. Development of commercially available vaccines is still far from reality, though research and trial programs continue. This book covers current research into drug therapeutics for the conditions caused by the parasites, which if viewed globally, pose an increasing threat to human health and welfare.
Up-to-the-minute information on the progress of research into tackling conditions caused by kinetoplastid parasites