Hot Topics in Infection and Immunity in Children IV contains chapters based on lectures given by speakers at the "Infection and Immunity in Children" course, held in June 2006 at Keble College, Oxford. It was the fourth annual course of this name and this is the fourth book in the series as well. Together the courses and books have become important components of the training available to paediatricians with an interest in this specialty and have become increasingly popular each year. This book covers topics in infectious diseases in children and is intended for Pediatric Infectious Disease trainees, trainers, and all those who manage children with infections.
Paediatric Infectious Diseases is now a recognised specialty in Europe with established training programmes and training centres, overseen by the European Society for Paediatric Infectious Diseases. This book and the course that precedes each edition will continue to play useful parts in the development and knowledge of specialists throughout the continent and beyond.
The editors of this volume Dr. Andrew Pollard, Dr. George McCracken, and Dr. Adam Finn are all leaders in the fields of paediatric medicine and infectious disease. Fast becoming a key text for pediatricians, this fourth outing for the Hot Topics series is once again culled from lectures given at the annual course on the subject at Keble College, Oxford. This is the first port of call for those who need to keep on top of the subject. With world-leading researchers as editors, the series has become a valuable addition to the sum of knowledge in this specialism and a resource for anyone dealing with infectious diseases in children.
Contributing Authors.- The Enteroviruses: an Emerging Infectious Disease? The Real, the Speculative...and the Really Speculative.- Mark J. Abzug.- Introduction.- Enterovirus 71: a "New" Neurologic Threat.- Modern Epidemiology and Clinical Presentations.- EV71 Brainstem Encephalitis.- EV71 Acute Flaccid Paralysis.- EV71 Diagnosis.- EV71 Pathogenesis.- EV71 History and the Emergence of Severe Epidemic Disease.- Therapy of EV71 Infection.- Congenital EV Infection.- Previous Evidence of In Utero EV Infection.- New Evidence for Congenital EV Infection: Amniotic Fluid Studies.- New Evidence for Congenital EV Infection: Placental Studies.- New Evidence of Congenital EV Infection: What Does it Mean?.- Chronic Fatigue Syndrome.- Evidence implicating EVs: the European Experience.- Evidence from Europe Not Implicating EVs.- New Evidence Implicating EVs: the American Experience.- Evidence Linking EV Infection and CFS: Possible Explanations.- Conclusions.- References.- Science and Society: The HIV Epidemic and South African Political Responses.- Hoosen M. Coovadia and Imraan Coovadia.- Introduction.- South Africa: The AIDS Advisory Committee.- Sarafina.- The Virodene Saga.- The Presidential AIDS Advisory Panel (Mbeki Panel, 2001).- The Durban Declaration.- The Enigma of President Mbeki.- Pragmatism.- Preoccupation with Governance.- The Politics of Negotiation.- AIDS and the Global Context.- Conclusion.- References.- Pathogenesis of Group A Streptococcal Infections and Their Sequelae.- Madeleine W. Cunningham.- Introduction.- Virulence Determinants and the Host Response.- Acute Rheumatic Fever.- 3.1 Immune Mechanisms in Rheumatic Carditis.- 3.1.1 Antibody Reacts with Valve Endothelium.- 3.1.2 T cell Infiltration through Valve Endothelium.- 3.1.3 Immune Mechanisms in Sydenham's Chorea.- Post-Streptococcal Glomerulonephritis.- Acknowledgements.- References.- 4. Snakes, Jellyfish and Spiders.- Bart J. Currie.- Introduction.- Toxins and clinical relevance.- Snakebite.- Jellyfish stings.- Spider bites.- Conclusions.- Acknowledgements.- References.- Current Status of Group A Streptococcal Vaccine Development.- James B. Dale.- Introduction.- Burden of Disease Caused by GAS Infections.- Current Strategies for Vaccine Development.- Rationale for M Protein-Based GAS Vaccines.- Preclinical Evaluation of a 26-Valent M Protein-Based Vaccine.- Clinical Experience with the 26-Valent GAS Vaccine.- Development of Vaccines Designed to Prevent Rheumatic Fever.- Summary and Conclusions.- Acknowledgements.- References.- New Aspects on Diagnosis and Transmission of Hepatitis B in Paediatric Patients and Pregnant Women.- Robert A. de Man, Annemiek van der Eijck and Irene Veldhuijzen.- Horizontal transmission of hepatitis B and the paediatric patient.- Infectivity of body fluids.- Implications for the paediatric patient.- Chronic hepatitis B in pregnancy.- References.- Pertussis Immunisation in Adolescents and Adults.- Ulrich Heininger.- Introduction.- Epidemiology.- 2.1 Incidence of pertussis disease compared to B. pertussis.- infections in adolescents and adults.- 2.2 Adolescents and adults as the source for pertussis in infants.- Disease.- Diagnosis.-Treatment.- Prevention by Immunisation.- Successful Childhood Programmes.- Expanding Programmes Beyond Childhood.- Summary.- References.- 8. Trachoma: Recent Developments.- David Mabey.- Introduction.- Epidemiology.- Trachoma assessment.- Clinical signs and C. trachomatis infection.- Pathogenesis of Trachoma.- The SAFE strategy.- Surgery.- Antibiotic.- References.- 9. Gonococcal Infections in Newborns and in Adolescents.- Noni MacDonald, Tim Mailman, Shalini Desai.- 1. Introduction.- 2. The Microbe.- 3. Gonococcal Infection in Newborns.- 4. Gonococcal Ophthalmia Neonatorum.- 5. Neonatal Gonococcal Scalp Abscess and Disseminated Gonococcal Infection.- 6. Diagnosis of Neonatal Gonococcal Infections.- 7. Treatment of Neonatal Gonococcal Infections.- 8. Prevention of Neonatal Gonococcal Infection.- 9. Gonococcal In
Fast becoming a key text for pediatricians, this fourth outing for the Hot Topics series is once again culled from lectures given at the annual course on the subject at Keble College, Oxford. This is the first port of call for those who need to keep on top of the subject. With world-leading researchers as editors, the series has become a valuable addition to the sum of knowledge in this specialism and a resource for anyone dealing with infectious diseases in children.