Overview: Regeneration and Repair. - Morphological Correlates of Regeneration and Repair in the Inner Ear.- The Recovery of Function in the Avian Auditory System Following Ototrauma.- Functional Recovery Following Hair Cell Regeneration in Birds.- Hair Cell Regeneration: Mechanisms Guiding Cellular Proliferation and Differentiation.- Protection and Repair of Inner Ear Sensory Cells.- Gene Arrays, Cell Lines, Stem Cells, and Sensory Regeneration in Mammalian Ears.
Not male pattern baldness, but the loss of sensory hair, is a very serious topic. Sensory hair cells convert sound and motion into our sense of hearing, movement, and head position. In mammals, the loss of hair cells is irreversible. Or is it? Hair cells in other vertebrates are capable of regenerating and recovering partial or complete function. This book provides a comprehensive survey of the regeneration of sensory hair cells.
Sensory hair cells in the inner ear and vestibular system convert mechanical stimuli, sound, and motion into neural activity that is responsible for the sensations of hearing, motion, and head position. In mammals, the loss of hair cells from acoustic over-stimulation, ototoxic drugs and aging is irreversible, leading to a permanent loss of function. However, it is now clear that hair cells in other vertebrates are capable of regenerating and recovering partial or complete function. This book provides a comprehensive survey of what is currently known about the regeneration, repair, and protection of sensory hair cells and the subsequent recovery of function in the auditory and vestibular systems. The editors and authors provide graduate students, clinicians, and scientists in the biological basis of hair cells and with an understanding of the factors that contribute to their regeneration and repair.