About the Series:
Fundamental Biomedical Technologies features titles in multidisciplinary, technology-driven areas, providing the foundations for breakthrough advances in medicine and biology. The term technology refers, in a vigorously unrestrictive sense, to a broad array of engineering disciplines, the sciences of computation and informatics, mathematical models exploiting and advancing methods of mathematical physics, and the development of novel, experimental discovery devices. Titles in this series are designed and selected to provide high-level visionary input for specialists, while presenting overviews of emerging fields for those in related areas. Volumes in this series aim to provide technologists with the material to gain competent entry into biomedical research and biomedical researchers to understand and embrace novel technological foundations and tools.
About the Series Editor:
Mauro Ferrari is a professor in the Brown Institute of Molecular Medicine, a professor of internal medicine in the division of cardiology, and the chairman of the department of biomedical engineering at the University of Texas Health Science Center in Houston, Texas. He holds concurrent professor appointments at the M.D. Anderson Cancer Center as professor of experimental therapeutics, and at Rice University in bioengineering. Dr. Ferrari is the current President of the Alliance for NanoHealth and he has spearheaded the development of the National Cancer Institute s nanotechnology programs. Dr. Ferrari is also the founder and Editor-in-Chief of Springer s archival journal Biomedical Microdevices.
Nanoparticles in Biomedical Imaging
Jeff W.M. Bulte and Michel M.J.J. Modo, Editors
Nanoparticles in Biomedical Imaging focuses on the use of nanoparticles as chemically engineered small entities that now have emerged as widely used diagnostic agents in biomedicine. The book is logically organized by the specific imaging modalities that are currently central in pre-clinical research and clinical routine, including magnetic resonance imaging, radionuclear imaging, ultrasound imaging, computed tomography, and optical imaging. This comprehensive title provides an expert opinion on the latest developments in biomedical imaging using nanoparticles.
Use of superparamagnetic iron oxide nanoparticles in magnetic resonance imaging
Radiolabeled liposomes and their applications in nuclear medicine
Ultrasound bubbles as acoustically reflective medium
Exploiting iodinated nanoparticles with computed tomography
Quantum dots: the bright future of semiconducting optical agents
Nanoparticles in Biomedical Imaging will serve as a useful and valuable resource on the fundamental science of diagnostic nanoparticles in their interactions with biological targets, providing a platform technology for clinical implementation and improved detection of disease.
About the Editors:
Jeff W.M. Bulte is currently a Professor of Radiology and a Professor of Chemical & Biomolecular Engineering at the Johns Hopkins University School of Medicine in Baltimore, USA. He serves as the Director of Cellular Imaging in the JHU Institute for Cell Engineering.
Michel M.J.J. Modo is the Wolfson Lecturer in Stem Cell Imaging at the Centre for the Cellular Basis of Behaviour and the MRC Centre for Neurodegeneration Research at the Institute of Psychiatry, King s College London.
Introduction: The Emergence of Nanoparticles as Imaging Platform in Biomedicine.- Introduction: The Emergence of Nanoparticles as Imaging Platform in Biomedicine.- (Para)magnetic Nanoparticles: Applications in Magnetic Resonance Imaging.- MR Lymphangiography Using Nano-Sized Paramagnetic Contrast Agents with Dendrimer Cores.- Use of USPIOs for Clinical Lymph Node Imaging.- Use of SPIOs for Clinical Liver Imaging.- The Emerging Role of USPIOs for MR Imaging of Atherosclerosis.- (Super)paramagnetic Nanoparticles: Applications in Noninvasive MR Imaging of Stem Cell Transfer.- Micron-Sized Iron Oxide Particles (MPIOs) for Cellular Imaging: More Bang for the Buck.- Molecular MR Imaging with Paramagnetic Perfluorocarbon Nanoparticles.- Magnetic Nanosensors for Probing Molecular Interactions.- Magnetoptical Probes.- Radiolabeled Nanoparticles: Applications in Nuclear Medicine.- Use of Radiolabeled Liposomes for Tumor Imaging.- Use of Radiolabeled Liposomes for Imaging of Infection and Inflammation.- Sulphur Colloid for Imaging Lymph Nodes and Bone Marrow.- Acoustically Reflective Nanoparticles: Application in Ultrasound Imaging.- Use of Ultrasound Bubbles in Lymph Node Imaging.- Use of Ultrasound Microbubbles for Vascular Imaging.- Targeted Microbubbles: Ultrasound Contrast Agents for Molecular Imaging.- Use of Acoustically Active Contrast Agents in Imaging of Inflammation and Atherosclerosis.- Iodinated Nanoparticles: Applications in Computed Tomography.- Iodinated Liposomes as Contrast Agents.- Quantum Dots: Applications in Optical Imaging.- Quantum Dots and Targeted Nanoparticle Probes for In Vivo Tumor Imaging.- Investigating the Dynamics of Cellular Processes at the Single Molecule Level with Semiconductor Quantum Dots.- Targeting Vascular Epitopes Using Quantum Dots.- Quantum Dots for Cancer Imaging.- Bimodal Liposomes and Paramagnetic QD-Micelles for Multimodality Molecular Imaging of Tumor Angiogenesis.
Introduction.- Use of Paramagnetic Dendrimers for Lymph Node Imaging.- Use of Uspios for Clinical Lymph Node Imaging.- Use of Spios for Clinical Liver Staging.- Use of Uspios for Imaging Xenograft Rejection.- Use of Uspios for Imaging of Arteriosclerosis.- Use of Spios for Labeling And Tracking of Stem Cells and Progenitors.- Use of Mpios for Cellular Imaging: More Bang for the Buck.- Use of Perfluorocarbon Emulsions for Specific MR Imaging of Sparse Molecular Epitopes.- Magnetic Nanosensors for Probing Molecular Interactions.- Magnetoptical Probes.- Use of Radiolabeled Liposomes for Tumor Targeting.- Use of Radiolabeled Liposomes for Imaging Infection/Inflammation.- Use of Sulfur Colloids for Imaging Bone Marrow/Lymph Nodes.- Use of Ultrasound Bubbles in Lymph Node Imaging.- Use of Ultrasound Bubbles for Vascular Imaging.- Ultrasound Bubbles.- Use of Ultrasound Bubbles for Specific Imaging of Fibrin Clots.- Use of Ultrasound Bubbles for Molecular Imaging In Atherosclerosis.- Use of Echogenic Liposomes In Imaging of Inflammation.- Use of Iodinated Emulsions as Liver Contrast Agent.- Use of Iodinated Emulsions as Tumor Specific Agent.- Developing Multicolored Quantum Dots.- Using of Quantum Dots for Intravital Fluorescent Microscopy.- Use of Quantum Dots for Targeting Vascular Epitopes.- Use of Quantum Dots for Lymph Node Imaging.- Use of Quantum Dots for Microscopic Tracking of Receptor Movement/Dynamics.- Use of Quantum Dots and Multiphoton Fluoresence Imaging in Living Mice.- Use of Quantum Dots for Imaging of Live Cells.
The current generation of imaging nanoparticles is diverse and dependent on its myriad of applications. This book provides an overview of how these imaging particles can be designed to fulfill specific requirements for applications across different imaging modalities. It presents, for the first time, a comprehensive interdisciplinary overview of the impact nanoparticles have on biomedical imaging and is a common central resource for researchers and teachers.
A nanoparticle is a microscopic particle with at least one dimension less than 100 nm. Nanoparticle research is an area of intense scientific research due to a wide variety of potential applications in biomedical, optical, and electronic fields. Written and edited by pioneers and innovators in the field, this book explains how nanoparticles can be designed to meet specific requirements for applications in distinct biomedical imaging modalities. With its interdisciplinary approach, the book draws on findings from a diverse range of fields. Illustrations help readers grasp key concepts and follow the steps for important processes. The book is intended for imaging researchers, chemists, physicists, biologists, pathologists and clinicians, giving them the foundation needed to make new discoveries and find new applications for nanoparticles in biomedical imaging.