Manufacturing of Microarrays.- Technological Platforms for Microarray Gene Expression Profiling.- Principles of Gene Microarray Data Analysis.- Gaining Weights and Feeling Good About It!- Complementary Techniques: RNA Amplification for Gene Profiling Analysis.- Complementary Techniques: Laser Capture Microdissection - Increasing Specificity of Gene Expression Profiling of Cancer Specimens.- Complementary Techniques: Validation of Gene Expression Data by Quantitative Real Time PCR.- Microarrays for Cancer Diagnosis and Classification.- Gene Profiling for the Prediction of Tumor Response to Treatment: the Case of Immunotherapy.- Identification of Molecular Determinants of Tumor Sensitivity and Resistance to Anticancer Drugs.- SNP and Mutation Analysis.- Cancer Development and Progression.- Gene Expression Profiling in Malignant Lymphomas.- Tumor Immunology.- Index.
Given the revolutionary implications that the use of this technology might have in the clinical management of cancer patients, the principles of DNA array-based tumor gene profiling must be clearly understood for the data to be correctly interpreted and appreciated. This book, written by leading experts, discusses the technical features characterizing the powerful laboratory tool of microarray technology, and reviews applications in the field of oncology.
Each chapter is written by a leader in the field
Contains detailed illustrations