I. Introduction.- Benefits of a translating research on inhibitory control for the prevention drug abuse.- II. Neurobehavioral Approaches for Understanding Inhibitory Control.- Animal models of inhibitory control.- Neurochemical influences on impulsivity and cognitive control in laboratory animals.- Genetic determinants of behavior and impulse control in alcoholic families.- Impaired inhibitory control as a mechanism in drug addiction.- Neuroimaging, adolescence, and risky behavior.- III. Translating Research on Inhibitory Control to At-Risk Populations.- Inhibitory control deficits in childhood and risk for substance use.- Translating basic science research findings into applications for prevention.- Impulsivity and adolescent substance use.- Positive and negative reinforcement processes underlying adolescent risk taking.- Developmental changes in neurocircuitry underlying impulse control and addiction vulnerability in adolescence.- Neurobehavioral disinhibition, brain activation, and risk for substance abuse.- IV. Translating Research on Inhibitory Control to Prevention Interventions.- Effects of adversity on development of inhibitory control and the role of parental involvement on prevention of adverse .- Preventing early conduct problems through a targeted intervention to strengthen inhibitory control and emotional regulation.- Developmental psychopathology: Focusing on core inhibitory competencies to prevent substance abuse.- Designing public service announcements that target impulsive or sensation-seeking adolescents to prevent drug abuse.- Preventive interventions designed to target underlying emotional regulatory mechanisms in high risk behaviors.- V. Conclusion.- Policy issues and advocacy translating research on inhibitory control to drug abuse prevention.- Final thoughts on inhibition and drug abuse: Where do we go from here?
The purpose of this book is to review our state of knowledge about the neurobehavioral and psychosocial processes involved in behavioral inhibitory processes and to provide an insight into how these basic research findings may be translated into the practice of drug abuse prevention interventions. Over the last decade, there has been a wealth of information indicating that substance use disorders do not simply reflect an exaggeration of reward seeking behavior, but that they also represent a dysfunction of behavioral inhibitory processes that are critical in exercising self-control. A number of studies have determined that individuals with substance use disorders have poor inhibitory control compared to non-abusing individuals. In addition, the fact that the adolescent period is often characterized by a lack of inhibitory control may be one important reason for the heightened vulnerability for the initiation of drug use during this time.
Controlled experiments utilizing neuroscience techniques in laboratory animals or neuroimaging techniques in humans have revealed that individual differences in prefrontal cortical regions may underlie, at least in part, these differences in inhibitory control. Although a few excellent journal reviews have been published on the role of inhibitory deficits in drug abuse, there has been relatively little attention paid to the potential applications of this work for drug abuse prevention. The current book will provide both basic and applied researchers with an overview of this important health-relevant topic. Since translational research cuts across multiple disciplines and most readers are not familiar with all of these disciplines, the reading level will be geared to be accessible to graduate students, as well as to faculty and researchers in the field.
The book will be organized around three general themes, encased within introductory and concluding chapt
On the cutting edge of neurobiology and drug abuse prevention
Puts emphasis on the translation of basic neurobiological science into drug abuse prevention
Worked with major granting agencies (most notably the National Institutes of Health)