Catalogs the known effects of chemical mixtures on the human body and proposes a framework for understanding and predicting their actions in terms of lipophile (fat soluble)/hydrophile (water soluble) interactions. This title presents a theoretical framework for predicting what the effects of uncharacterized mixtures might be.
In this important reference work, Zeliger catalogs the known effects of chemical mixtures
on the human body and also proposes a framework for understanding and predicting their
actions in terms of lipophile (fat soluble) / hydrophile (water soluble) interactions. The
author's focus is on illnesses that ensue following exposures to mixtures of chemicals
that cannot be attributed to any one component of the mixture.
In the first part the mechanisms of chemical absorption at a molecular and
macromolecular level are explained, as well as the body's methods of defending itself
against xenobiotic intrusion. Part II examines the sources of the chemicals discusssed,
looking at air and water pollution, food additives, pharmaceuticals, etc. Part III, which
includes numerous case studies, examines specific effects of particular mixtures on
particular body systems and organs and presents a theoretical framework for predicting
what the effects of uncharacterized mixtures might be. Part IV covers regulatory
requirements and the need to adjust recommended exposure levels for products
containing mixtures. It also contains recommendations on how to limit exposure to
mixtures in the products we use and on how to limit release of mixtures into the
environment.
Providing brief summaries of each mixture and its effects, Zeliger provides a
comprehensive reference, a jumping off point for professionals (with extensive chapter
bibliographies) and an introduction to the topic for those studying traditional toxicology.
Addressing many inadequately understood illnesses and conditions such as asthma,
infertility and cancer, it will also be of interest to health professionals, environmental
scientists and lawyers.
- Presents a theoretical framework for predicting the effects of chemical mixtures for which no specific data exists (this predictive aspect is important due to the vast number of different potential chemical combinations - far too many to comprehensively catalog)
- A quick and convenient source of hard to come by data on the rapidly developing field of chemical mixtures, for groups including chemists and engineers, toxicologists, health professionals and environmental scientists
- New and updated material comprises over 30% of this timely new edition, which includes the latest research data alongside an expanded introduction to the science and art of predicting the toxicological properties of chemical mixtures
PART I
1) Introduction to Chemical Toxicology of Mixtures
2) Health Effects of Exposures to Chemical Mixtures
3) Absorption of Chemical Mixtures
4) Chemical Toxicology
PART II Exposures to Chemical Mixtures
5) Scope and sources of toxic exposures
6) In Utero Exposure
7) Air Pollution
8) Water Pollution
9) Soil Pollution
10) Food
11) Chemicals In and Around The Home
12) Sick Building Syndrome
13) Industrial Exposure
14) Pesticides
15) Alcohol and Tobacco: Recreational Toxins
16) Electromagnetic Radiation and Toxic Exposure
PART III Mixture Effects on Body Systems
17) Respiratory System
18) Nervous System
19) Developmental Neurotoxicology
20) Autism: Effect of Maternal Exposure to Neurotoxic Chemcials
21) Attention Deficit Hyperactivity Disorder (ADHD)
22) Endocrine System
23) Toxic Infertility
24) Teratogens
25) Immune System
26) Chemical Sensitivity: Multiple Chemical Sensitivity (MCS)
27) Skin
28) Musculoskeletal System
29) Cardiovascular System
30) Liver
31) Kidneys
32) Cancer
33) Childhood Cancer
34) Cancer Clusters
PART IV Regulatory Requirements
35) Regulatory Requirements
36) Conclusions and Recommendations
Zeliger, Harold
Dr. Harold I. Zeliger holds a Ph.D. in organic chemistry and has been a professor of chemistry and environmental science. He is a Certified Professional Chemist, a Board- Certified Forensic Examiner, and an EPA Certified Laboratory Director. Dr. Zeliger is the author of 51 technical publications, including basic research journal articles and patents. In his more than 40 years in the Chemical Process Industry, he has personally developed many industrial and consumer chemical products, designed chemical product warning labels and written Material Safety Data Sheets for toxic and flammable chemicals. Dr. Zeliger has investigated hundreds of toxic chemical exposures, environmental spills and discharges, chemical fires and explosions nationally and internationally. He has served repeatedly as an expert witness for both plaintiffs and defendants in chemical product, process, toxic exposure, environmental, flammable, intellectual property and subrogation claims.
Dr. Zeliger has provided services for numerous forensic examinations, technology transfer and due diligence investigations. Dr. Zeliger's research is in the area of chemical toxicology. His published work includes papers on the toxic effects of chemical mixtures and chemical causes of cancer clusters and two editions of Human Toxicology of Chemical Mixtures, Second Edition.
Klappentext
Catalogs the known effects of chemical mixtures on the human body and proposes a framework for understanding and predicting their actions in terms of lipophile (fat soluble)/hydrophile (water soluble) interactions. This title presents a theoretical framework for predicting what the effects of uncharacterized mixtures might be.
