This is the authoritative introduction to the concepts and techniques of recombinant DNA research and their dramatic results. The book explores core concepts in molecular biology in a contemporary inquiry-based context, building its coverage around the landmark experiments that redefined our understanding of DNA. As a result, students learn how working scientists make real high-impact discoveries. Included are chapters on applications to human diseases, cancer, and forensics.
Foundations of DNAOverviewDNA is the Primary Genetic MaterialFrom DNA to ProteinBasics of Gene ExpressionBasic Tools of Recombinant DNAFundamental Features of GenesGetting DNA into Cells and OrganismsMoveable ElementsEpigeneticsRNAi Foundations of Genomics Overview Sequencing a Small Genome How the Human Genome was SequencedAnalyzing GenomesOverviewSequence AnalysisGenome-wide Functional AnalysisGenomic Approaches to Human BiologyHunting Human Disease Genes Cancer Genomics DNA and Justice
Über den Autor
JAMES D. WATSON is the Chancellor of Cold Spring Harbor Laboratory, USA, and was awarded the Nobel Prize (1962) for his discoveries concerning the molecular structure of nucleic acids.
AMY A. CAUDY is a Lewis-Steiger Fellow, at the Lewis-Steiger Institute for Integrative Genomics at Princeton University, USA. Combining methods from genomics, and biochemistry, her research seeks to understand the regulation of mitochondrial replication and abundance.
RICHARD M. MYERS is the Stanford W. Ascherman Professor and Chairman of the Department of Genetics at Stanford University, USA. He studies the structure, function and evolution of the human genome to understand roles that genes play in human diseases such as Huntington disease, Parkinson disease, hypertension, insulin resistance, and atherosclerosis.
JAN A. WITKOWSKI is the Executive Director of the Banbury Center, USA, the Editor-in-chief of Trends in Biochemical Sciences and a professor at the Watson School of Biological Sciences. Prior to his role at Cold Spring Harbor, he ran a research lab focused on the DNA-based diagnosis of human genetic diseases.
Inhaltsverzeichnis
Foundations of DNA
Overview
DNA is the Primary Genetic Material
From DNA to Protein
Basics of Gene Expression
Basic Tools of Recombinant DNA
Fundamental Features of Genes
Getting DNA into Cells and Organisms
Moveable Elements
Epigenetics
RNAi
Foundations of Genomics
Overview
Sequencing a Small Genome
How the Human Genome was Sequenced
Analyzing Genomes
Overview
Sequence Analysis
Genome-wide Functional Analysis
Genomic Approaches to Human Biology
Hunting Human Disease Genes
Cancer Genomics
DNA and Justice
Klappentext
This is the authoritative introduction to the concepts and techniques of recombinant DNA research and their dramatic results. The book explores core concepts in molecular biology in a contemporary inquiry-based context, building its coverage around the landmark experiments that redefined our understanding of DNA.
Elite author team, including James Watson, winner of a Nobel Prize for his central part in the discovery of the structure of the DNA double helix
New fundamentals version uses cutting edge research, techniques, and practical applications of genome sequencing to highlight the core concepts that students in genetics and molecular biology learn
Written in a conversational style by top scientists
