Über den Autor
Malcolm D. Richardson - University Hospital of South Manchester and Manchester Academic Health Science Centre, University of ManchesterrnDavid W. Warnock - National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
Preface to the fourth edition, xxvirnPreface to the first edition, xxviiirnAcknowledgements, xxixrn1 Introduction, 1rn1.1 The nature of fungi, 1rn1.2 Classification and nomenclature of fungi and fungal diseases, 3rn1.3 Fungi as human pathogens, 5rn1.4 The changing pattern of fungal infection, 7rn1.5 New directions in diagnosis, 9rn1.6 New directions in treatment and prevention, 10rn2 Laboratory diagnosis of fungal infection, 12rn2.1 Introduction, 12rn2.2 Collection of specimens, 13rn2.3 Specimens for serological tests, 18rn2.4 Specimens for antifungal drug level determinations, 18rn2.5 Transport of specimens, 18rn2.6 Interpretation of laboratory test results, 18rn2.7 Molecular diagnosis of fungal infection, 28rn3 Antifungal drugs, 32rn3.1 Introduction, 32rn3.2 Allylamines, 32rn3.4 Other allylamine compounds for topical administration, 35rn3.5 Azoles, 35rn3.6 Fluconazole, 40rn3.7 Itraconazole, 44rn3.8 Ketoconazole, 48rn3.9 Posaconazole, 50rn3.10 Voriconazole, 53rn3.11 Other imidazole compounds for topical administration, 57rn3.12 Echinocandins, 59rn3.13 Anidulafungin, 60rn3.14 Caspofungin, 61rn3.15 Micafungin, 63rn3.16 Polyenes, 65rn3.17 Amphotericin B, 66rn3.18 Other polyene compounds for topical administration, 76rn3.19 Flucytosine, 76rn3.20 Griseofulvin, 79rn3.21 Other miscellaneous compounds for topical administration, 81rn3.22 Prophylactic treatment for prevention of fungal infection, 82rn3.23 Empirical treatment of suspected fungal infection in the neutropenic patient, 84rn3.24 Pre-emptive antifungal treatment, 85rn3.25 Combination antifungal treatment of invasive fungal infections, 85rn3.26 Laboratory monitoring, 86rn4 Dermatophytosis, 91rn4.1 Introduction, 91rn4.2 The causal organisms and their habitat, 92rn4.3 Epidemiology, 93rn4.4 Laboratory diagnosis of dermatophytosis, 94rn4.5 Tinea capitis, 95rn4.6 Tinea corporis, 102rn4.7 Tinea cruris, 105rn4.8 Tinea pedis, 107rn4.9 Tinea manuum, 111rn4.10 Tinea unguium, 113rn5 Superficial candidosis, 121rn5.1 Definition, 121rn5.2 Geographical distribution, 121rn5.3 The causal organisms and their habitat, 121rn5.4 Epidemiology, 122rn5.5 Clinical manifestations, 124rn5.6 Essential investigations and their interpretation, 130rn5.7 Management, 130rn5.8 Prevention, 136rn6 Other cutaneous fungal infections, 138rn6.1 Pityriasis versicolor, 138rn6.2 Other Malassezia infections, 142rn6.3 Piedra, 143rn6.4 White piedra, 144rn6.5 Black piedra, 145rn6.6 Tinea nigra, 147rn6.7 Neoscytalidium infection, 148rn6.8 Alternaria infection, 149rn7 Mould infections of nails, 151rn7.1 Definition, 151rn7.2 Geographical distribution, 151rn7.3 The causal organisms and their habitat, 151rn7.4 Epidemiology, 152rn7.5 Clinical manifestations, 152rn7.6 Differential diagnosis, 153rn7.7 Essential investigations and their interpretation, 153rn7.8 Management, 154rn7.9 Prevention, 155rn8 Keratomycosis, 156rn8.1 Definition, 156rn8.2 Geographical distribution, 156rn8.3 The causal organisms and their habitat, 156rn8.4 Epidemiology, 157rn8.5 Clinical manifestations, 158rn8.6 Essential investigations and their interpretation, 159rn8.7 Management, 160rn9 Otomycosis, 162rn9.1 Definition, 162rn9.2 Geographical distribution, 162rn9.3 The causal organisms and their habitat, 162rn9.4 Epidemiology, 162rn9.5 Clinical manifestations, 163rn9.6 Differential diagnosis, 164rn9.7 Essential investigations and their interpretation, 164rn9.8 Management, 164rn10 Aspergillosis, 166rn10.1 Definition, 166rn10.2 Geographical distribution, 166rn10.3 The causal organisms and their habitat, 166rn10.4 Epidemiology, 167rn10.5 Clinical manifestations, 170rn10.6 Essential investigations and their interpretation, 182rn10.7 Management, 186rn10.8 Empirical treatment of suspected invasive aspergillosis, 194rn10.9 Prevention, 195rn11 Invasive candidosis, 201rn11.1 Definition, 201rn11.2 Geographical distribution, 201rn11.3 The causal organisms and their habitat, 201rn11.4 Epidemiology, 202rn11.5 Clinical manifestations, 208rn11.6 Candidosis in special hosts, 217rn11.7 Essential investigations and their interpretation, 217rn11.8 Management, 221rn11.9 Empirical treatment of suspected invasive candidosis, 232rn11.10 Prevention, 232rn12 Cryptococcosis, 236rn12.1 Definition, 236rn12.2 Geographical distribution, 236rn12.3 The causal organisms and their habitat, 236rn12.4 Epidemiology, 238rn12.5 Clinical manifestations, 240rn12.6 Essential investigations and their interpretation, 244rn12.7 Management, 246rn12.8 Prevention, 251rn13 Mucormycosis, 253rn13.1 Definition, 253rn13.2 Geographical distribution, 253rn13.3 The causal organisms and their habitat, 253rn13.4 Epidemiology, 254rn13.5 Clinical manifestations, 256rn13.6 Differential diagnosis, 259rn13.7 Essential investigations and their interpretation, 259rn13.8 Management, 260rn13.9 Prevention, 262rn14 Pneumocystosis, 264rn14.1 Definition, 264rn14.2 Geographical distribution, 264rn14.3 The causal organisms and their habitat, 264rn14.4 Epidemiology, 265rn14.5 Clinical manifestations, 268rn14.6 Differential diagnosis, 269rn14.7 Essential investigations and their interpretation, 270rn14.8 Management, 271rn14.9 Prevention, 274rn15 Blastomycosis, 277rn15.1 Definition, 277rn15.2 Geographical distribution, 277rn15.3 The causal organism and its habitat, 277rn15.4 Epidemiology, 278rn15.5 Clinical manifestations, 279rn15.6 Differential diagnosis, 282rn15.7 Essential investigations and their interpretation, 282rn15.8 Management, 283rn15.9 Prevention, 286rn16 Coccidioidomycosis, 288rn16.1 Definition, 288rn16.2 Geographical distribution, 288rn16.3 The causal organisms and their habitat, 288rn16.4 Epidemiology, 289rn16.5 Clinical manifestations, 291rn16.6 Differential diagnosis, 294rn16.7 Essential investigations and their interpretation, 294rn16.8 Management, 297rn16.9 Prevention, 301rn17 Histoplasmosis, 304rn17.1 Definition, 304rn17.2 Geographical distribution, 304rn17.3 The causal organism and its habitat, 305rn17.4 Epidemiology, 305rn17.5 Clinical manifestations, 307rn17.6 Differential diagnosis, 312rn17.7 Essential investigations and their interpretation, 313rn17.8 Management, 316rn17.9 Prevention, 320rn18 Paracoccidioidomycosis, 322rn18.1 Definition, 322rn18.2 Geographical distribution, 322rn18.3 The causal organism and its habitat, 322rn18.4 Epidemiology, 323rn18.5 Clinical manifestations, 324rn18.6 Differential diagnosis, 327rn18.7 Essential investigations and their interpretation, 327rn18.8 Management, 329rn18.9 Prevention, 331rn19 Chromoblastomycosis, 332rn19.1 Definition, 332rn19.2 Geographical distribution, 332rn19.3 The causal organisms and their habitat, 332rn19.4 Epidemiology, 333rn19.5 Clinical manifestations, 333rn19.6 Differential diagnosis, 334rn19.7 Essential investigations and their interpretation, 334rn19.8 Management, 335rn20 Entomophthoromycosis, 338rn20.1 Introduction, 338rn20.2 Basidiobolomycosis, 338rn20.3 Conidiobolomycosis, 341rn21 Mycetoma, 344rn21.1 Definition, 344rn21.2 Geographical distribution, 344rn21.3 The causal organisms and their habitat, 344rn21.4 Epidemiology, 346rn21.5 Clinical manifestations, 346rn21.6 Differential diagnosis, 347rn21.7 Essential investigations and their interpretation, 348rn21.8 Management, 349rn22 Sporotrichosis, 352rn22.1 Definition, 352rn22.2 Geographical distribution, 352rn22.3 The causal organism and its habitat, 352rn22.4 Epidemiology, 353rn22.5 Clinical manifestations, 354rn22.6 Differential diagnosis, 356rn22.7 Essential investigations and their interpretation, 357rn22.8 Management, 358rn22.9 Prevention, 360rn23 Hyalohyphomycosis, 362rn23.1 Introduction, 362rn23.2 Fusarium infection, 362rn23.3 Scedosporium infection, 369rn23.4 Other agents of hyalohyphomycosis, 373rn24 Penicillium marneffei infection, 376rn24.1 Introduction, 376rn24.2 Geographical distribution, 376rn24.3 The causal organism and its habitat, 376rn24.4 Epidemiology, 377rn24.5 Clinical manifestations, 378rn24.6 Differential diagnosis, 378rn24.7 Essential investigations and their interpretation, 379rn24.8 Management, 380rn24.9 Prevention, 381rn25 Phaeohyphomycosis, 383rn25.1 Introduction, 383rn25.2 Geographical distribution, 384rn25.3 The causal organisms and their habitat, 384rn25.4 Epidemiology, 385rn25.5 Clinical manifestations, 387rn25.6 Differential diagnosis, 390rn25.7 Essential investigations and their interpretation, 391rn25.8 Management, 392rn26 Other invasive yeast infections, 396rn26.1 Introduction, 396rn26.2 Systemic Malassezia infection, 396rn26.3 Trichosporonosis, 399rn26.4 Other yeast infections, 402rn27 Unusual fungal and pseudofungal infections, 405rn27.1 Introduction, 405rn27.2 Adiaspiromycosis, 405rn27.3 Lacaziosis, 408rn27.4 Pythiosis, 410rn27.5 Rhinosporidiosis, 414rnFurther reading, 416rnSelect bibliography, 419rnIndex, 421
Fungal Infection: Diagnosis and Management, 4th Edition is a concise and up-to-date guide to the clinical manifestations, laboratory diagnosis and management of superficial, subcutaneous and systemic fungal infections.rnThis highly acclaimed book has been extensively revised and updated throughout to ensure all drug and dosage recommendations are accurate and in agreement with current guidelines. A new chapter on infections caused by Pneumocystis jirovecii has been added. The book has been designed to enable rapid information retrieval and to help clinicians make informed decisions about diagnosis and patient management. Each chapter concludes with a list of recent key publications which have been carefully selected to facilitate efficient access to further information on specific aspects of fungal infections.rnClinical microbiologists, infectious disease specialists, as well as dermatologists, hematologists and oncologists, can depend on this contemporary text for authoritative information and the background necessary to understand fungal infections.