Über den Autor
Dr Kandice Kottke-Marchant, MD PhD, Section Head, Hemostasis and Thrombosis, Department of Clinical Pathology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA and President, International Society of Laboratory Hematology. She is also a Professor of Pathology at the Cleveland Clinic Lerner College of Medicine and an Adjunct Professor of Biomedical Engineering at Case Western Reserve University. She has published over 100 peer-reviewed publications in the field of haemostasis, is an international expert on platelet testing and aspirin resistance, and has served on review panels from the National Institutes of Health (NIH), College of American Pathologists (CAP), ISO/TC212 and North American Specialized Coagulation Laboratory Association (NASCOLA). She has been a driving force to increase the international visibility and impact of the ISLH. She has been responsible for running the ISLH annual Symposia since 2002. Due to her involvement in haemostasis and the ISLH, Dr. Kottke-Marchant will be uniquely positioned to serve as one of the co-Editors of the Textbook of Laboratory Hematology.rnElkin Simson, MD, PCAP, FACSP is the Medical Director of the Center for Clinical Laboratories and Hematology Laboratory at the Mount Sinai Hospital. He is also Associate Professor and Vice Chairman of the Department of Pathology at the Mount Sinai School of Medicine, New York, NY, USA. Dr. Simson was formerly the Vice-President for Medical and Scientific Affairs at Technicon Instruments Corporation, where he participated in the development of the first automated haematology analyzers to combine the CBC and WBC differential into a single instrument. Dr Simson is the Past President of the ISLH and is Vice-President of the International Council for Standardization in Hematology (ICSH). He has been Chairman of the Hematology Area Committee of NCCLS (now CLSI), a member of Council of the National Reference System for the Clinical Laboratory (NRSCL) and the Hematology and Quality Improvement Subcommittees of the NCCCLS. He was a member of the Hematology and Pathology Advisory Panel of the Food and Drug Administration (FDA). Due to his long-time involvement in haematology automation and standards organizations, Dr. Simson is an idea co-editor.rnThe proposed section editors are chosen from international experts in their respective fields; most have also been long-time ISLH members who have been faculty at one or more ISLH Symposia and who have been repeatedly recognized as outstanding speakers and contributors by the participants. Dr Bruce Davis is one of the co-founders of the ISLH and has a long history of involvement in developing automated cellular and flow cytometric technologies. Professor Alberto Orfao from Spain is one of the world's foremost experts on flow cytometry. Professor Samuel Machin is currently President of the British Society of Haematology and is an international authority on haemostasis testing. Stefanie McFadden is a medical technologist who is sought after as a consultant for laboratory management and informatics issues.
Contributors, viiirnPreface, xiiirnAbbreviations, xvrnI Cellular Analysis, 1rn1 Historical Perspective on Cellular Analysis, 3nElkin Simsonrn2 Cellular Morphologic Analysis of Peripheral Blood, 10nPowers Peterson, Sheila McNeill, and Gene Gulatirn3 Automated Cell Analysis: Principles, 26nBruce H. Davis and Patrick W. Barnesrn4 Differential Leukocyte Analysis, 33nMarie-Christine Béné and Francis Lacombern5 Automated Platelet Analysis, 48nCarol Briggs and Samuel J. Machinrn6 Method Standardization in Cellular Analysis, 59nIan Giles & Richard Kendallrn7 Spurious counts and spurious results on hematology analyzers: platelets, 66nMarc Zandecki, Franck Genevieve, Jérémie Gérard, and Alban Godonrn8 Spurious Counts and Spurious Results on Hematology Analyzers: White Blood Cells, Red Blood Cells, Hemoglobin, Red Cell Indices, and Reticulocytes, 79nMarc Zandecki, Franck Genevieve, Jérémie Gérard, and Alban Godonrn9 Evaluation of Hematology Analyzers, 96nCarol BriggsrnII Flow Cytometry in Hematologic Diagnosis, 103rn10 Flow Cytometric Specimen Collection, Processing, and Reporting, 105nMaryalice Stetler-Stevenson, Bruce Greig, Constance Yuanrn11 Validation and Quality Control in Clinical Flow Cytometry, 115nNorman B. Purvis and Teri Oldakerrn12 A New Paradigm for Cytometric Analysis, 131nC. Bruce BagwellrnIII Molecular Diagnostics, 143rn13 Sample Collection, Processing, and Storage for Molecular Genetic Testing, 145nBobby L. Boyanton Jr. and Domnita Crisanrn14 Development of Amplification-Based Molecular Genetic Testing in Hematology, 155nRaymond R. Tubbsrn15 Single Nucleotide Polymorphisms in Molecular Diagnostics, 168nGurunathan Murugesan, Seongsoo Jang, and Jin-Yeong Hanrn16 Molecular Cytogenetic (FISH) Analysis of Hematolymphoid Disorders, 181nMark A. Micale and Anwar N. Mohamedrn17 Immunoglobulin and T-Cell Receptor Gene Rearrangement Analysis for Diagnosis of Hematologic Malignancies, 199nJacques J. M. van Dongen, Anton W. Langerak, and Tomasz Szczepan skirn18 Minimal Residual Disease Detection in Acute Myeloid Leukemia by RQ-PCR and Multiparameter Flow Cytometry, 220nWolfgang Kern and Susanne Schnittgerrn19 Engraftment Analysis using Short Tandem Repeats following Allogeneic Hematopoietic Cell Transplantation, 234nIlka Warshawsky and Hyun-Sook Chirn20 Molecular Profiling Methods in the Diagnosis of Hematologic Disorders, 244nAnnette S. Kim, Stephen R. Master, and Cherie H. Dunphyrn21 The Role of Classical Cytogenetics in Hematologic Diagnosis, 267nKathleen RichkindrnIV Bone Marrow Analysis, 279rn22 Bone Marrow Processing and Normal Morphology, 281nKarl S. Theilrn23 Cytochemical, Immunocytochemical, Histochemical, and Immunohistochemical Staining of Bone Marrow and Peripheral Blood, 300nAlexandra Rice and Barbara J. Bainrn24 The Myeloproliferative Neoplasms, 315nSindhu Cherian and Brent L. Woodrn25 Myelodysplastic Disorders, 331nMaryalice Stetler-Stevenson, Joseph A. DiGiuseppe, and Diane C. Arthurrn26 Acute Leukemias, 345nJoseph A. DiGiuseppe and Laila Mnayerrn27 Lymphoproliferative Disorders, 364nRobert W. Allan, Samer Z. Al-Quran, Ying Li, and Raul C. Braylanrn28 Plasma Cell Disorders, 381nBill G. Richendollar and James R. Cookrn29 Diagnosis of Adult Mastocytosis: Role for Bone Marrow Analysis, 388nLuis Escribano, Andrés Garcia-Montero, Laura Sanchez-Muñoz, Cristina Teodosio, Ivan Alvarez-Twose, Maria Jara-Acevedo, José Mario Morgado, Julia Almeida, Alberto Orfao for the Spanish Network on Mastocytosis (REMA)rn30 Paroxysmal Nocturnal Hemoglobinuria (PNH) Analysis, 399nStephen J. RichardsrnV Hemostasis and Thrombosis, 407rn31 Sample Collection and Processing in Hemostasis, 409nDorothy M. Adcockrn32 Performance and Interpretation of Routine Coagulation Assays, 420nKandice Kottke-Marchantrn33 Clotting Factors and Inhibitors: Assays and Interpretation, 435nPiet Meijer, H. W. Verbruggen, and Michael Spannaglrn34 Diagnosis of von Willebrand Disease, 447nEmmanuel J. Favaloro and Jerry Kouttsrn35 Diagnosis of Fibrinolytic Disorders, 460nWayne Chandlerrn36 Laboratory Evaluation of Acquired Coagulation Disorders, 468nRichard A. Marlar and Katerine Seywerdrn37 Platelet Assays and Platelet Dysfunction, 480nPaul Harrison and David Keelingrn38 Thrombophilia: Assays and Interpretation, 492nSophia Yohe and John Olsonrn39 Lupus Anticoagulants, Antiphospholipid Antibodies, and Antiphospholipid Syndrome, 509nWilliam L. Nichols, Kandice Kottke-Marchant, Marlies R. Ledford-Kraemer, Henry A. Homburger, Layna K. Cardelrn40 Heparin-Induced Thrombocytopenia, 526nSixten Selleng and Andreas Greinacherrn41 Anticoagulant, Antiplatelet, and Thrombolytic Drugs, 535nLaura Green and Samuel J. Machinrn42 Guidelines for Evaluation of Coagulation Analyzers and Coagulation Testing, 543nChris GardinerrnVI Special Hematology Techniques, 553rn43 Essentials of Immunohematology, 555nA. Bradley Eisenbreyrn44 Analysis of Hemoglobinopathies, Hemoglobin Variants and Thalassemias, 562nMonica V. E. Gallivan and Piero C. Giordanorn45 Nutritional Anemia, 586nRalph Greenrn46 Hemolytic Anemias Associated with Disorders of Erythrocyte Membrane and Cytoskeleton Proteins, 602nMay-Jean King, Lesley J. Bruce, Didier Dhermyrn47 Body Fluid Analysis, 615nDavid J. Blomberg, Katherine Galagan, and Eric F. Glassyrn48 Malaria Analysis, 626nQigui Li, Peter J. Weina, and R. Scott Millerrn49 Erythrocyte Sedimentation Rate (ESR), 638nJosep M. JournVII Point-of-Care Testing, 647rn50 Needs Analysis and Selection of Point-of-Care Testing Analyzers, 649nAlbert Huismanrn51 Point-of-Care Testing in Hemostasis, 655nSteve Kitchen and Dianne Kitchenrn52 Point-of-Care Hematology Assays, 668nAlbert HuismanrnVIII Management of Information 673rn53 Laboratory Management, 675nStefanie L. McFadden and Linda M. Sandhausrn54 Hematology Quality Practices 686nGeorge S. Cembrowskirn55 Digital Imaging in Hematology, 707nDanny Hsu and Szu-Hee LeernIndex, 719
Expertly edited and endorsed by the International Society for Laboratory Hematology, this is the newest international textbook on all aspects of laboratory hematology. Covering both traditional and cutting-edge hematology laboratory technology this book emphasizes international recommendations for testing practices. Illustrative case studies on how technology can be used in patient diagnosis are included. Laboratory Hematology Practice is an invaluable resource for all those working in the field.