Preface Chapter 1: Regulation of Melnoma Progression by the Tumor Microenvironment: the Roles of PAR-1 and PAFR.nGabriel J. Villares and Menashe Bar-Eli Chapter 2: Functions of Autocrine Motility Factor at the Tumor Microenvironment.nTatsuyoshi Funasaka and Avraham Raz Chapter 3: Targeting Signaling Pathways - in the search of Melanoma's Achilles' heel.nNikolas K. Haass, Christoph Hoeller and Meenhard Herlyn Chapter 4: Regulation of Gene Expression in Tumor and Non-Tumor Cells in the Tumor Microenvironment. Impact of ErbB2 Over-Expression on Tumor and Tumor Microenvironment that facilitate tumor progression and metastasis.nValerie Stone Hawthorne and Dihua Yu Chapter 5: Intercellular and Cytoskeletal Signaling Converge at PAK's.nAnupama E. Gururaj and Rakesh Kumar Chapter 6: Molecular Basis for Vascular Endothelial Growth Factor Expression Tumor.nKeping Xie and James Yao Chapter 7: Incipent Event in Human carcinogenesis: A Concept of Forerunner Genes.nBogdan Czerniak
It is now becoming very clear that the development and progression of tumor towards the malignant (metastatic) phenotype depends tightly on the interaction between the tumor cells and the tumor microenvironment. Tumor cells respond to stimuli generated within the tumor microenvironment for their growth advantage while the tumor cell themselves reshape and remodel the architecture and function of their extracellular matrices. The term tumor microenvironment is a wide umbrella consisting of stromal cells such as fibroblasts and endothelial cells and infiltration immune cells including T and B cells, macrophages, and other inflammatory cells (PMNs). These different components of the tumor microenvironment could have stimulatory and inhibitory effects on tumor progression by regulating the gene expression repertoire within the tumor cells on one hand and the stroma cells on the other. In this volume we have seven contributors who will discuss several different aspects on the cross talk within the tumor microenvironment components leading to the acquisition of the metastatic phenotype. It is our hope that these state-of-the-art studies will shed further light on our understanding of these complicated processes.
Describes the contribution of the tumor microenvironment to tumor growth and metastasis
Gives a unique opportunity to understand the cross talk between tumor cells (the seed) and the organ microenvironment (the soil)
Discusses therapy targeting the microenvironment rather than the tumor cells