Preface Legend to the frontispiece Part 1 Origin Of Bacteria 1. Origin Of Life Based On Physical Principles 2. Preamble To Life 3. The First Cell 4. Development Of Cell Physiology And Diversity Part 2 Wall Structure 5. Covalent Bonds And Tensile Strength Of Biomaterials 6. Structure Of The Fabric That Covers A Bacterium 7. The Covalently-Linked Sacculus: The Nona-Muropeptide Model 8. The Structure Of The Tessera : I.E. The Unit Structure Of The Wall Surface 9. Extrusion And Incorporation Into The Wall 10. The Role Of Poles In The Growth Strategy Of Bacteria Part 3 Bacterial Morphologies 11. Sidewalls Of Gram-Negative Rod-Shaped Bacteria 12. Growth Strategies For Gram-Positive Cells 13. Wall Growth Strategies For Gram-Negative Cells 14. Commas, Vibrios, Spirilla, And Helicobacters; Tapered And Branched Bacteria 15. Spirochetes And Spiroplasma And The Special Strategies For CWD (Cell Wall Deficient) Cells 16. Coccal Versus Rods-Shaped Cell And The First Bacterium 17. Diseases: Old And New, Especially Part 4 Antibiosis 18. Lysozymes As Alternatives To ß-Lactams Antibiotics Acting On The Bacterial Wall 19. Development Of Wall Antibiotics And Bacterial Counter-Measures 20. Antibiotics And Resistance, With An Emphasis On Aminoglycosides 21. Future Chemotherapy Aimed At The Bacterial Murein References
Understanding antibiotic chemotherapy at the ecological level is necessary for more permanent advances in development and in the usage of antibiotic agents. This book traces the history of bacteria, from the development of life on earth to the evolution of diversity. It is this diversity that led, almost automatically to the development of pathogens as well as antibiotics. If we are to create long term antibiotics we must design them with this history in mind.
Unique in its very broad perspective and its explanation of how medicine has arrived at its present position