This book is the proceedings of Falk Symposium 157, entitled Chronic Hepatitis: Metabolic, Cholestatic, Viral and Autoimmune , held in Freiburg, Germany, on 10--11 October 2006 (one of three symposia during the XIII Falk Liver Week 2006). It provides up-to-date information on new developments in the field of chronic hepatitis and its various entities.
In recent decades we have learned how heterogeneous the clinical entity of chronic hepatitis has become. The liver, as the central organ of metabolism and detoxification, is more than ever a target of disease processes evolving from the spread of obesity in the western world. Apart from nonalcoholic steatohepatitis (NASH), alcoholic liver disease is still the most prevalent liver disease in the west. Alcohol-induced liver disease exhibits a broad clinical spectrum from alcoholic steatohepatitis to cirrhosis. Alcoholic hepatitis is a disease entity with a particular poor prognosis. Any liver disease of unknown cause is suspected as being drug-associated. Every new drug metabolized in the liver has the potential to damage the liver. Primary biliary cirrhosis has seen significant progress due to the identification of new risk factors based on new epidemiological studies. Interface hepatitis has become a prognostic marker as well as a therapeutic target. The treatment of autoimmune hepatitis has progressed significantly due to an individualized approach to immunosuppression.
Most challenging remains the treatment of viral hepatitis. The treatment of chronic hepatitis Band C has significantly improved due to numerous new drugs. For those patients with chronic hepatitis where either the cause is unknown or where treatment cannot prevent disease progression, understanding the mechanisms of fibrogenesis is a particular challenge. Once cirrhosis has developed as a consequence of the interplay between necrosis, apoptosis, inflammation and regeneration, the successful prevention and management of complications of cirrhosis determines the prognosis of the individual patient. Therefore, understanding and managing complications of liver cirrhosis is of particular importance to the individual patient. Once end-stage liver disease has developed, liver transplantation is a hope and not a threat to the patient. The field of liver transplantation has seen significant progress due to the latest developments to overcome organ shortage including living related organ donations.
The book also contains two highlights: the Wolfgang Gerok State of the Art Lecture on the occasion of his 80th birthday, and the presention of the second international Dame Sheila Sherlock Award.
List of principal contributors
List of chairpersons
SECTION I: METABOLIC AND TOXIC HEPATITIS.- 1 NASH: bench to bedside -- lessons from animal models.- 2 Alcohol-induced hepatitis: pathophysiology and treatment.- 3 Drug-induced hepatitis.- SECTION II: CHOLESTATIC HEPATITIS
4 Liver disease in pregnancy: diagnosis and treatment.- 5 Geoepidemiology of primary biliary cirrhosis.-6 Interface hepatitis in primary biliary cirrhosis: prognostic marker and therapeutic target.- SECTION III: VIRAL HEPATITIS (PART 1).- 7 Pathobiology of hepatitis B virus infection.- 8 Individualized treatment of hepatitis C.- SECTION IV: VIRAL HEPATITIS (PART 2).- 9 The future in the treatment of hepatitis C.- 10 Treatment of interferon non-responder patients with chronic hepatitis C in Asia.- SECTION V: AUTOIMMUNE HEPATITIS.- 11 Update on autoimmune hepatitis.- 12 Overlap syndromes Laudatio on the occasion of Professor Gerok's 80th birthday.- 13 Wolfgang Gerok State-of-the-Art Lecture: Pathogenesis of hepatic encephalopathy.- SECTION VI: SEQUELAE OF CHRONIC HEPATITIS (PART 1) Presentation of the International Dame Sheila Sherlock Award.- 14 Award Lecture: Past, present and future of hepatology.- 15 Progression of chronic hepatitis: from inflammation to fibrosis.- 16 Treatment of portal hypertension and variceal bleeding.- 17 Management of ascites and spontaneous bacterial peritonitis.- SECTION VII: SEQUELAE OF CHRONIC HEPATITIS (PART 2).- 18 Advances in the pathogenesis and treatment of type 1 and type 2 hepatorenal syndrome.- 19 Hepatopulmonary syndrome.- 20 Hepatocellular carcinoma
This book contains the proceedings of Falk Symposium 157, entitled Chronic Hepatitis: Metabolic, Cholestatic, Viral and Autoimmune, held in Freiburg, Germany, in October 2006: one of three symposia during the XIII Falk Liver Week 2006. It provides up-to-date information on new developments in the field of chronic hepatitis and its various entities.
Interdisciplinary symposium bringing together basic science and clinical applications. Up-to-date research findings at the highest scientific level