This book presents the latest findings in mechanosensitive ion channel research compiled by a number of internationally recognized experts in the field of mechanosensitivity, specializing in mechanosensitive or mechanically gated ion channels and the underlying mechanosensitive signaling cascades. "Mechanosensitivity in Cells and Tissues: Mechanosensitive Ion Channels" defines and discusses key problems of cellular mechanobiology, describing the methods for studying mechanosensitive ion channels, the role of lipid bilayer mechanics in mechanosensation, and the molecular organization, physiology and pharmacology of the various ion channels, which react to changes in cellular membrane tension. The book provides a comprehensive description of mechanotransduction, which is defined as the biochemical response of cells to mechanical stimulation, and provides the reader with the latest vision of signaling cascades. These signaling cascades play an important role in modulation of function of mechanosensitive ion channels, as well as their reaction to changes in activity of mechanosensitive ion channels, located upstream of these cascades. This volume includes chapters describing different ways and effects of mechanical stimulation in various tissues and cells, which will be of particular interest for students and specialists, interested in the field of mechanosensitivity research.
In summary, descriptions of the most widely used experimental models, the methods of choice and references to experimental protocols, the latest experimental findings and current vision, and potential problems in data interpretation, will be of considerable use to all those interested in this field of research.
Foreword I.- Foreword II.- Editorial Mechanically gated channels and mechanosensitive channels.- Part I. Mechanosensitive Channels.- Experimental methods of studying of mechanosensitive channels and possible errors in data interpretation.- The role of lipid bilayer mechanics in mechanosensation.- Mechanosensitive channels gated by membrane tension: bacteria and beyond.- Computational approaches in studies of bacterial mechanosensitive channels.- Mechanosensory transduction in the nematode Caenorhabditis elegans.- Mechanosensitive ion channels in odontoblasts.- Potassium ion channels in articular chondrocytes: putative roles in mechanotransduction, metabolic regulation and cell proliferation.- Osmotransduction through volume-sensitive Cl - channels.- Mechanosensitive channel TRPV4. A micro-machine converting physical force into an ion flow. Part II Mechanosensitive Signaling Cascades.- Mechanosensitive purinergic calcium signalling in articular chondrocytes.- Signal transduction pathways involved in mechanotransduction in osteoblastic and mesenchymal stem cells.- Caveolae: Co-ordinating centres for mechanotransduction in the heart?- Multimodal activation and regulation of neuronal mechanosensitive cation channels.- Rregulation of intracellular signal transduction pathways by mechanosensitive ion channels. Part III. Cell Mechanobiology.- The effects of mechanical stimulation on vertebrate hearts: a question of class.- Mechanobiology of fibroblasts
Mechanosensitive Channels.- Experimental Methods of Studying Mechanosensitive Channels and Possible Errors in Data Interpretation.- Role of Lipid Bilayer Mechanics in Mechanosensation.- Mechanosensitive Channels Gated by Membrane Tension.- Computational Studies of the Bacterial Mechanosensitive Channels.- Mechanosensory Transduction in the Nematode Caenorhabditis elegans.- Mechanosensitive Ion Channels in Odontoblasts.- Potassium Ion Channels in Articular Chondrocytes.- Osmotransduction Through Volume-Sensitive Cl- Channels.- Mechanosensitive Channel TRPV4.- Mechanosensitive Signalling Cascades.- Mechanosensitive Purinergic Calcium Signalling in Articular Chondrocytes.- Signal Transduction Pathways Involved in Mechanotransduction in Osteoblastic and Mesenchymal Stem Cells.- Caveolae.- Multimodal Activation and Regulation of Neuronal Mechanosensitive Cation Channels.- Regulation of Intracellular Signal Transduction Pathways by Mechanosensitive Ion Channels.- Cell Mechanobiology.- The Effects of Mechanical Stimulation on Vertebrate Hearts.- Mechanobiology of Fibroblasts.
This book explores the latest data dealing with mechanosensitive channels research results. It was compiled by a group of internationally recognized scientists leading in the field of mechanosensitive ion channels or mechanically gated channels and signaling cascades research. Key problems of cell mechanobiology are also discussed. As a whole, the volume dwells on the major issues of mechanical stress influencing the ion channels and intracellular signaling pathways.
One book concentrates on basic information on mechanosensitive ion channels
One book concentrates on basic information on mechanosensitive signaling cascades
Covers basic ideas on cell mechanobiology
Criticizes a number of points considered acute in the recent years
Gives a wide and detailed coverage of the problem as a whole