This book brings together the world's leading authorities on tumor immunology. This book describes the basic immunology principles that form the foundation of understanding how the immune system recognizes and rejects tumor cells. The role of the innate and adaptive immune responses is discussed and the implications of these responses for the design of clinical strategies to combat cancer are illustrated.
Part 1 General Principles of Tumor Immunology Chapter 1: A Perspective on Cancer Immunology and Immunotherapy by Alan N. Houghton Chapter 2: Tumor Antigens by Michael A. Morse, Timothy M. Clay and H. Kim Lyerly Chapter 3: T Cells and Antigen Recognition by Leisha A. Emens Chapter 4: The Role of Natural Killer T cells in Tumor Immunity by Madhav V. Dhodapkar Chapter 5: Immunomodulatory Molecules of the Immune System by Yvonne M. Saenger, Robert R. Jenq, and Miguel-Angel Perales Chapter 6: HLA class I antigen abnormalities in tumors by Barbara Seliger and Soldano Ferrone Chapter 7: The Local Tumor Microenvironment by Theresa L. Whiteside Part 2 Tumor Vaccines Chapter 8: Peptide and Protein Vaccines for Cancer by Raymond M. Wong and Jeffrey S. Weber Chapter 9: DNA Vaccines Against Cancer by Adam D. Cohen and Jedd D. Wolchok Chapter 10: Recombinant and Viral Bacterial Vaccines by Douglas W. Grosenbach, Jarett Feldman, Jeffrey Schlom and Scott I. Abrams Chapter 11: Dendritic Cell Vaccines by Sylvia Adams, Nina Bhardwaj and David W. O'Neill Chapter 12: Whole Cell Vaccines by Mark B. Faries and Donald L. Morton Chapter 13: Carbohydrate Vaccines against Cancer by Philip O. Livingston and Govind Ragupathi Part 3 Passive Immunotherapy Approaches Chapter 14: Monoclonal Antibody Therapy of Cancer by Joseph G. Jurcic, Deborah A. Mulford, and David A. Scheinberg Chapter 15: Adoptive Cellular Therapy for the Treatment of Cancer by Cassian Yee Chapter 16: Checkpoint Blockade and Combinatorial Immunotherapies by Karl S. Peggs, Sergio A. Quezada and James P. Allison Part 4 Clinical Tumor Immunotherapy Chapter 17: General Approaches to Measuring Immune Responses by Mary L. Disis and Keith L. Knutson Chapter 18: Interferon Therapy by Stergios J. Moschos and John M. Kirkwood Chapter 19: High Dose Interleukin-2Therapy by Christian A Petrulio, Gail DeRaffele and Howard L. Kaufman Chapter 20: Monoclonal Antibodies in Cancer Therapy by Christoph Rader and Michael R. Bishop Chapter 21: Unmasking Tumor Cell Immunogenicity by Chemotherapy: Implications for Therapy by Irma Larma, Robbert G van der Most and Richard A. Lake
Describes how the immune system can be harnessed to recognize and kill tumor cells
Illustrates how current advances in immunology are being used in tumor immunotherapy
Details the rationale and indications for tumor immunotherapy
Discusses some of the current obstacles to successful tumor immunotherapy
Brings together the world's leading experts in tumor immunology