Defending Life discusses the relationship between hosts and parasites. A major contention of the book is that the immune system depends ontologically on the ecosystem in which it is embedded; it would not have the features it has if it was not related in one way or other to parasitic agents and to the host s own cells and tissues. To sustain the argument, life is investigated at all layers from molecules up through cells, organisms and ecosystems. Together with the inverse course, which goes from ecological contingencies down to gene-expression profiles, the approach facilitates an advanced understanding of immunocompetence as well as its converse, immunoincompetence. The emphasis on analytical abstractions, coherent patterns and generative mechanisms makes possible the distinction between genuine causality and coincidental associations, and thus increases the understanding of why we observe what we observe. The book contains detailed descriptions of the immune system and the microbial world as well as methodological and conceptual clarifications.
"The book is highly recommended to those who want to dig into the scientific challenges involved in understanding the complex demands and tasks that nature had bestowed the immune system. "
Professor Roland Jonsson
The Gade Institute, University of Bergen, Norway.
From the contents
Introduction. Preface.- 1 Tracks of thought.- 2 Immunobiology.- 3 Adaptive plasticity.- 4 Natura naturans.- 5 Disabled defences.- References. Index.
From the reviews:
"Defending Life is one of the serious efforts to understand the science of immunology theoretically ... . This book is not only an important contribution towards understanding the restrictions under which immunology now functions, but it provocatively suggests how the discipline might reorient itself to address more effectively not only the molecular mechanisms of immune reactions, but also their regulations and organization. ... a propitious step towards the full adoption of immunology by philosophy of biology as a member in good standing." (Alfred I. Tauber, Perspectives in Biology and Medicine, Vol. 51 (2), 2008)
Introduction Preface 1 Tracks of thought 1.1 Organismal maintenance 1.2 The war metaphor 1.3 Metaimmunological musings 2 Immunobiology 2.1 The received view 2.2 The integrated view 2.3 The many and the one 3 Adaptive plasticity 3.1 Totalities of involvement 3.2 Equipping the adaptive toolbox 3.3 Exemption explained 4 Natura naturans 4.1 Situating life 4.2 Social evolution 4.3 Coevolutionary dynamics 5 Disabled defences 5.1 Failure to perform 5.2 The re-enacting of ancient conflicts 5.3 Environmental challenges References Index
Defending Life discusses the relationship between hosts and parasites. It contains detailed descriptions of the immune system and the microbial world as well as methodological and conceptual clarifications. Its emphasis on analytical abstractions, coherent patterns and generative mechanisms makes possible the distinction between genuine causality and coincidental associations and increases the understanding of why we observe what we observe.
Dynamics of host-parasite relations
A novel understanding of disease