Forward; Anne E. Cress and Raymond B. Nagle Chapter 1: Changing Extracellular Matrix Ligands during Metastasis; Elisabeth L. Bair and Raymond B. Nagle Chapter 2: Suppression and Alteration of Adhesion Structures in Human Epithelial Cancer Progression; Tracy L. Davis, Aaron J. Goldman and Anne E. Cress Chapter 3: Regulation of Cadherins during Prostate Cancer Progression; Ronald L. Heimark and Nelson R. Alexander Chapter 4: The Actin Cytoskeleton and Metastasis; Isaac Rabinovitz and Kaylene J. Simpson Chapter 5: Characterization of the Ferm Domain Protein EHM2 in Human Cancer Cells; Sanjay Chauhan, Ryan Childers, Jennifer Himes, Andrea Pierce, Sabrina Sykes, Kelvin W. Pond, Susan Kunz and Roger L. Miesfeld Chapter 6: Cytokeratin 6 Expression in Prostate Stem Cells; Monika Schmelz and Anil Prasad Chapter 7: Epigenetic Regulation of Genes That Affect Tumor Cell Adhesion; Bernard W. Futscher and Frederick E. Domann Chapter 8: Cell Adhesion-Mediated Radiation Resistance: The Role of Integrins and Integrin Proximal Protein; Nils Cordes Chapter 9: CAM-DR: Hanging on For Cell Survival; Lori A. Hazlehurst Chapter 10: Epithelial Cell Surface Targeting Using Synthetic D-Amino Acid Peptides; Thomas C. Sroka, Anne E. Cress, and Kit S. Lam
This volume highlights the expression of specific adhesion molecules within human cancer tissues. It details the expression signatures from published DNA microarray and immunohistochemistry studies. Coverage discusses the concept that the alteration of specific adhesion molecules influence the cancer migration ability and cancer damage responses, both features are essential for the survival of an invading tumor cell.
Compiled information on cell adhesion molecules in human cancer tissue specimens
Explains how cell adhesion influences DNA damage responses
Explains how cell adhesion influences chemotherapeutic drug resistance