1: Viruses And The Innate Immune System, Megan L. Shaw and Peter Palese. n2: How Viruses Elicit Interferon Production, David E. Levy and Isabelle J. Marié. n3: Genes Modulated By Interferons And Double-Stranded RNA, Saumendra N. Sarkar, Gregory A. Peters and Ganes C. Sen. n4: Immunoevasive Strategies: Host And Virus, Markus Wagner, Shahram Misaghi and Hidde L. Ploegh. n5: Interferon Antagonists Of Influenza Viruses, Adolfo García-Sastre. n6: The Anti-Interferon Mechanisms Of Paramyxoviruses, Nicola Stock, Stephen Goodbourn and Richard E. Randall. n7: The Strategy Of Conquest, Sunil J. Advani and Bernard Roizman. n8: Immunomodulation By Poxviruses, James B. Johnston and Grant McFadden. n9: Interferon Antagonists Encoded By Emerging RNA Viruses, Christopher F. Basler. n10: Viral Pathogenesis And Toll-Like Receptors, Susan R. Ross. n11: Digesting Oneself And Digesting Microbes, Montrell Seay, Savithramma Dinesh-Kumar and Beth Levine. n12: Genetic Variation In Host Defenses And Viral Infections, Eunhwa Choi and Stephen J. Chanock. nIndex.
This book is an excellent, up-to-date reference on a relatively young area of research in which virology, cellular biology and molecular pathogenesis govern the principles of coinvestigation. Thus, the book will be of great interest to virologists, molecular immunologists and biologists, and biochemists but also to clinical pharmacologists in the long-term search for new antiviral agents. Ulrich Desselberger, Gif-sur-Yvette/Cambridge.
Infection of a naïve (non-immune) host with a virus elicits an immediate response which results in a cascade of changes in the host, including an interferon response (innate immunity). The outcome of this interaction is influenced by the genes of the virus as well as the genes of the host. Interestingly, different viruses do it in different ways. Not only is there a plethora of mechanisms used by the invading organisms, but the host has also evolved a great variety of redundant and robust countermeasures. This interplay of host and virus represents one of the most significant frontiers in biology today. A clearer understanding of the mechanisms involved will arm us with better strategies to deal with viruses, including emerging pathogens and potential bioterrorism agents. This book is sure to benefit students, scientists, and physicians working in the areas of virology, immunology, microbiology, and infectious diseases. Pharmaceutical industry professionals will also find interest in this illuminating look into virus/host interactions.
The interplay of host and virus represents one of the most significant frontiers in biology today
Provides a clearer understanding of the mechanisms involved to arm us with better strategies to deal with viruses, including emerging pathogens and potential bioterrorism agents