Molecular Biology of Tumors.- Brain Tumors.- Immunophenotypic Characterization of Infiltrating Poly- and Mononuclear Cells in Childhood Brain Tumors.- Anti-Neoplastic Biological Therapies.- Experimental Therapies in Brain Tumors.- Biologic Anti-Neoplastic Therapies.- The Lymphokine Activeted Killer (LAK) Cell Phenomenon.- Angiogenesis Inhibition in Anti-Neoplastic Therapy.- Antigen Presentation by Dendritic Cells and Their Significance in Anti-Neoplastic Immunotherapy.- Genetically Engineered Antibodies for Direct Anti-Neoplastic Treatment and Systematic Delivery of Various Therapeutic Agents to Cancer Cells.- Cancer-Testis Antigens: Promising Targets for Antigen Directed Anti-Neoplastic Immunotherapy.- Prologue.- Materials and Methods.
Childhood brain tumors are a diverse group of diseases characterized by the abnormal growth of tissue contained within the skull. Other than leukemia and lymphoma, brain tumors are the most common type of neoplasms that occur in children. The leading cause of death from childhood neoplasms among persons up to 19 years is brain tumors. As such, this book is a review of the most recent molecular biological research concerning brain tumors with references and comparisons to a variety of neoplastic disorders. The book then uses this information to foreshadow the direction that future anti-neoplastic therapies will take. Because of the wide spectrum of the objectives of the book, any individual involved in cancer research will greatly benefit from the work. Histopathologists, neuropathologists, clinical and research oncologists, and medical students will find this book to be an invaluable resource as a reference guide. Patients and their families will also find the book useful as it offers a comprehensive update on new, non-classical therapeutic modality options and contains a detailed description and analysis of brain tumors. Such an endeavor has yet to be undertaken by any other book and may prove to be the most comprehensive book on brain tumors thus far.