Includes cutting-edge methods and protocols
Provides step-by-step detail essential for reproducible results
Contains key notes and implementation advice from the experts
This third edition volume expands on the previous editions with updated chapters on longitudinal studies, randomized trials, evidence-based decisions making, and a new section on changing health-related behaviors. The chapters in this book are organized into six parts: Part One focuses on framing clinical research questions and choosing a suitable design; biases that may occur in clinical research; and the ethics associated with doing conducting research on humans. Parts Two through Four discuss designs, measurements, and analysis that pertain to evaluation of risk in longitudinal studies; assessment of therapy in controlled trials; and evaluation of diagnostic tests. Part Five presents methods used in various components of evidence-based decision-making; and Part Six highlights interventions focused on changing health-related behaviors. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of various types of bias, step-by-step, readily reproducible protocols for different research designs, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and thorough, Clinical Epidemiology: Methods and Protocols, Third Edition is a valuable resource for clinicians and researchers who want to expand their works to humans and use their findings in the health system.
Preface...
Table of Contents...
Contributing Authors...
Part I Introduction
1. On Framing the Research Question and Choosing the Appropriate Research Design
Patrick S. Parfrey and Pietro Ravani
2. Bias in Clinical Research
Susan Stuckless and Patrick S. Parfrey
3. Definitions of Bias in Clinical Research
Geoffrey Warden
4. Research Ethics for Clinical Researchers
John D. Harnett
5. Ethical, Legal, and Social Issues (ELSI) in Clinical Genetics Research
Daryl Pullman and Holly Etchegary
Part II Longitudinal Studies
6. Longitudinal Studies 1: Determinants of Risk
Sean W. Murphy
7. Longitudinal Studies 2: Modeling Data using Multivariate Analysis
Pietro Ravani, Brendan J. Barrett, and Patrick S. Parfrey
8. Longitudinal Studies 3: Data Modeling using Standard Regression Models and Extensions
Pietro Ravani, Brendan J. Barrett, and Patrick S. Parfrey
9. Longitudinal Studies 4: Matching Strategies to Evaluate Risk
Matthew T. James
10. Longitudinal Studies 5: Development of Risk Prediction Models for Patients with Chronic Disease
Navdeep Tangri and Claudio Rigatto
Part III Randomized Controlled Trials
11. Randomized Controlled Trials 1: Design
Bryan M. Curtis, Brendan J. Barrett, and Patrick S. Parfrey
12. Randomized Controlled Trials 2: Analysis
Robert N. Foley and Patrick S. Parfrey
13. Randomized Controlled Trials 3: Measurement and Analysis of Patient-Reported Outcomes
Michelle M. Richardson and Klemens B. Meyer
14. Randomized Controlled Trials 4: Planning, Analysis, and Interpretation of Quality of Life Studies
Robert N. Foley and Patrick S. Parfrey
15. Randomized Controlled Trials 5: Biomarkers and Surrogates/Outcomes
Claudio Rigatto and Brendan J. Barrett
16. Randomized Controlled Trials 6: Determining the Sample Size and Power for Clinical Trials and Cohort Studies
Tom Greene
17. Randomized Controlled Trials 7: On Contamination and Estimating the Actual Treatment Effect
Patrick S. Parfrey
Part IV Other Clinical Epidemiology Methods
18. Evaluation of Diagnostic Tests
Brendan J. Barrett and John M. Fardy
19. Genetic Epidemiology of Complex Phenotypes
Darren D. O´Rielly and Proton Rahman
20. Qualitative Research in Clinical Epidemiology
Stephanie Thompson and Kara Schick-Makaroff
Part V Methods in Evidence-Based Decision Making
21. Evidence Based Decision Making 1: Critical Appraisal
Laurie K. Twells
22. Evidence Based Decision Making 2: Systematic Review and Meta-Analysis
Aminu Bello, Ben Vandermeer, Natasha Wiebe, Amit X. Garg, and Marcello Tonelli
23. Evidence-Based Decision Making 3: Health Technology Assessment
Daria O´Reilly, Richard Audas, Kaitryn Campbell, Meredith Vanstone, James M. Bowen, Lisa Schwartz, Nazila Assasi, and Ron Goeree
24. Evidence-Based Decision Making 4: Clinical Practice Guidelines
Tae Won Yi, Sine Donnellan, and Adeera Levin
25. Evidence-Based Decision Making 5: Knowledge Translation and the Knowledge to Action Cycle
Braden J. Manns
26. Evidence-Based Decision Making 6: Administrative Databases as Secondary Data Source for Epidemiologic and Health Service Research
Tanvir Turin Chowdhury and Brenda R. Hemmelgarn
27. Methods in Evidence-Based Decision Making 7: Health Economics in Clinical Research
Braden J. Manns
28. Methods in Evidence-Based Decision Making 8: A Primer for Researchers
Victor Maddalena and Maisam Najafizada
Part VI Changing Health-Related Behaviors
29. Changing Health-Related Behaviors 1: Patient-Oriented Research and Patient Engagement in Health Research
Catherine Street, Laurie K. Twells, Toni Leamon, Lynn Taylor, and Holly Etchegary
30. Changing Health-Care Behaviors 2: On Improving the Value of Health Spending
Karen Dickson, Robert Wilson, Owen Parfrey, and Patrick S. Parfrey
31. Changing Health-Related Behaviors 3: Lessons from Implementation Science
Amanda Hall, Helen Richmond, Krista Mahoney, and James Matthews
32. Changing Health-Related Behaviors 4: Realizing Impact of Health Research through Knowledge Translation
Kate Lambert, Krista Mahoney, and Patrick S Parfrey
33. Changing Health-Related Behaviors 5: On Interventions to Change Physician Behaviors
Cheryl Etchegary, Lynn Taylor, Krista Mahoney, Owen Parfrey, and Amanda Hall
34. Changing Health-Related Behaviors 6: Analysis, Interpretation, and Application of Big Data
Randy Giffen and Donald Bryant
Subject Index List...
This third edition volume expands on the previous editions with updated chapters on longitudinal studies, randomized trials, evidence-based decisions making, and a new section on changing health-related behaviors. The chapters in this book are organized into six parts: Part One focuses on framing clinical research questions and choosing a suitable design; biases that may occur in clinical research; and the ethics associated with doing conducting research on humans. Parts Two through Four discuss designs, measurements, and analysis that pertain to evaluation of risk in longitudinal studies; assessment of therapy in controlled trials; and evaluation of diagnostic tests. Part Five presents methods used in various components of evidence-based decision-making; and Part Six highlights interventions focused on changing health-related behaviors. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of various types of bias, step-by-step, readily reproducible protocols for different research designs, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and thorough, Clinical Epidemiology: Methods and Protocols, Third Edition is a valuable resource for clinicians and researchers who want to expand their works to humans and use their findings in the health system.
On Framing the Research Question and Choosing the Appropriate Research Design.- Bias in Clinical Research.- Definitions of Bias in Clinical Research.- Research Ethics for Clinical Researchers.- Ethical, Legal, and Social Issues (ELSI) in Clinical Genetics Research.- Longitudinal Studies 1: Determinants of Risk.- Longitudinal Studies 2: Modeling Data using Multivariate Analysis.- Longitudinal Studies 3: Data Modeling using Standard Regression Models and Extensions.- Longitudinal Studies 4: Matching Strategies to Evaluate Risk.- Longitudinal Studies 5: Development of Risk Prediction Models for Patients with Chronic Disease.- Randomized Controlled Trials 1: Design.- Randomized Controlled Trials 2: Analysis.- Randomized Controlled Trials 3: Measurement and Analysis of Patient-Reported Outcomes.- Randomized Controlled Trials 4: Planning, Analysis, and Interpretation of Quality of Life Studies.- Randomized Controlled Trials 5: Biomarkers and Surrogates/Outcomes.- Randomized Controlled Trials 6: Determining the Sample Size and Power for Clinical Trials and Cohort Studies.- Randomized Controlled Trials 7: On Contamination and Estimating the Actual Treatment Effect.- Evaluation of Diagnostic Tests.- Genetic Epidemiology of Complex Phenotypes.- Qualitative Research in Clinical Epidemiology.- Evidence Based Decision Making 1: Critical Appraisal.- Evidence Based Decision Making 2: Systematic Review and Meta-Analysis.- Evidence-Based Decision Making 3: Health Technology Assessment.- Evidence-Based Decision Making 4: Clinical Practice Guidelines.- Evidence-Based Decision Making 5: Knowledge Translation and the Knowledge to Action Cycle.- Evidence-Based Decision Making 6: Administrative Databases as Secondary Data Source for Epidemiologic and Health Service Research.- Methods in Evidence-Based Decision Making 7: Health Economics in Clinical Research.- Methods in Evidence-Based Decision Making 8: A Primer for Researchers.- Changing Health-Related Behaviors 1: Patient-Oriented Research and Patient Engagement in Health Research.- Changing Health-Care Behaviors 2: On Improving the Value of Health Spending.- Changing Health-Related Behaviors 3: Lessons from Implementation Science.- Changing Health-Related Behaviors 4: Realizing Impact of Health Research through Knowledge Translation.- Changing Health-Related Behaviors 5: On Interventions to Change Physician Behaviors.- Changing Health-Related Behaviors 6: Analysis, Interpretation, and Application of Big Data.
Inhaltsverzeichnis
Preface...
Table of Contents...
Contributing Authors...
Part I Introduction
1. On Framing the Research Question and Choosing the Appropriate Research Design
Patrick S. Parfrey and Pietro Ravani
2. Bias in Clinical Research
Susan Stuckless and Patrick S. Parfrey
3. Definitions of Bias in Clinical Research
Geoffrey Warden
4. Research Ethics for Clinical Researchers
John D. Harnett
5. Ethical, Legal, and Social Issues (ELSI) in Clinical Genetics Research
Daryl Pullman and Holly Etchegary
Part II Longitudinal Studies
6. Longitudinal Studies 1: Determinants of Risk
Sean W. Murphy
7. Longitudinal Studies 2: Modeling Data using Multivariate Analysis
Pietro Ravani, Brendan J. Barrett, and Patrick S. Parfrey
8. Longitudinal Studies 3: Data Modeling using Standard Regression Models and Extensions
Pietro Ravani, Brendan J. Barrett, and Patrick S. Parfrey
9. Longitudinal Studies 4: Matching Strategies to Evaluate Risk
Matthew T. James
10. Longitudinal Studies 5: Development of Risk Prediction Models for Patients with Chronic Disease
Navdeep Tangri and Claudio Rigatto
Part III Randomized Controlled Trials
11. Randomized Controlled Trials 1: Design
Bryan M. Curtis, Brendan J. Barrett, and Patrick S. Parfrey
12. Randomized Controlled Trials 2: Analysis
Robert N. Foley and Patrick S. Parfrey
13. Randomized Controlled Trials 3: Measurement and Analysis of Patient-Reported Outcomes
Michelle M. Richardson and Klemens B. Meyer
14. Randomized Controlled Trials 4: Planning, Analysis, and Interpretation of Quality of Life Studies
Robert N. Foley and Patrick S. Parfrey
15. Randomized Controlled Trials 5: Biomarkers and Surrogates/Outcomes
Claudio Rigatto and Brendan J. Barrett
16. Randomized Controlled Trials 6: Determining the Sample Size and Power for Clinical Trials and Cohort Studies
Tom Greene
17. Randomized Controlled Trials 7: On Contamination and Estimating the Actual Treatment Effect
Patrick S. Parfrey
Part IV Other Clinical Epidemiology Methods
18. Evaluation of Diagnostic Tests
Brendan J. Barrett and John M. Fardy
19. Genetic Epidemiology of Complex Phenotypes
Darren D. O'Rielly and Proton Rahman
20. Qualitative Research in Clinical Epidemiology
Stephanie Thompson and Kara Schick-Makaroff
Part V Methods in Evidence-Based Decision Making
21. Evidence Based Decision Making 1: Critical Appraisal
Laurie K. Twells
22. Evidence Based Decision Making 2: Systematic Review and Meta-Analysis
Aminu Bello, Ben Vandermeer, Natasha Wiebe, Amit X. Garg, and Marcello Tonelli
23. Evidence-Based Decision Making 3: Health Technology Assessment
Daria O'Reilly, Richard Audas, Kaitryn Campbell, Meredith Vanstone, James M. Bowen, Lisa Schwartz, Nazila Assasi, and Ron Goeree
24. Evidence-Based Decision Making 4: Clinical Practice Guidelines
Tae Won Yi, Sine Donnellan, and Adeera Levin
25. Evidence-Based Decision Making 5: Knowledge Translation and the Knowledge to Action Cycle
Braden J. Manns
26. Evidence-Based Decision Making 6: Administrative Databases as Secondary Data Source for Epidemiologic and Health Service Research
Tanvir Turin Chowdhury and Brenda R. Hemmelgarn
27. Methods in Evidence-Based Decision Making 7: Health Economics in Clinical Research
Braden J. Manns
28. Methods in Evidence-Based Decision Making 8: A Primer for Researchers
Victor Maddalena and Maisam Najafizada
Part VI Changing Health-Related Behaviors
29. Changing Health-Related Behaviors 1: Patient-Oriented Research and Patient Engagement in Health Research
Catherine Street, Laurie K. Twells, Toni Leamon, Lynn Taylor, and Holly Etchegary
30. Changing Health-Care Behaviors 2: On Improving the Value of Health Spending
Karen Dickson, Robert Wilson, Owen Parfrey, and Patrick S. Parfrey
31. Changing Health-Related Behaviors 3: Lessons from Implementation Science
Amanda Hall, Helen Richmond, Krista Mahoney, and James Matthews
32. Changing Health-Related Behaviors 4: Realizing Impact of Health Research through Knowledge Translation
Kate Lambert, Krista Mahoney, and Patrick S Parfrey
33. Changing Health-Related Behaviors 5: On Interventions to Change Physician Behaviors
Cheryl Etchegary, Lynn Taylor, Krista Mahoney, Owen Parfrey, and Amanda Hall
34. Changing Health-Related Behaviors 6: Analysis, Interpretation, and Application of Big Data
Randy Giffen and Donald Bryant
Subject Index List...
Klappentext
This third edition volume expands on the previous editions with updated chapters on longitudinal studies, randomized trials, evidence-based decisions making, and a new section on changing health-related behaviors. The chapters in this book are organized into six parts: Part One focuses on framing clinical research questions and choosing a suitable design; biases that may occur in clinical research; and the ethics associated with doing conducting research on humans. Parts Two through Four discuss designs, measurements, and analysis that pertain to evaluation of risk in longitudinal studies; assessment of therapy in controlled trials; and evaluation of diagnostic tests. Part Five presents methods used in various components of evidence-based decision-making; and Part Six highlights interventions focused on changing health-related behaviors. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of various types of bias, step-by-step, readily reproducible protocols for different research designs, and tips on troubleshooting and avoiding known pitfalls.
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Cutting-edge and thorough, Clinical Epidemiology: Methods and Protocols, Third Edition is a valuable resource for clinicians and researchers who want to expand their works to humans and use their findings in the health system.
rn
rn
Includes cutting-edge methods and protocols
Provides step-by-step detail essential for reproducible results
Contains key notes and implementation advice from the experts
