This volume examines the current state of free radical biology as it impacts on hepatic disorders. It takes a thorough look at the relationship of oxidative stress in acute and chronic disease and takes into account factors like: redox biomarkers; antioxidant defense and protection; cell signaling, mutations; oxidative damage involving lipids, proteins and nucleic acids; membrane trafficking, inflammation, mitochondrial dysfunction, alterations in immunological function and toxicology and hypoxia. Studies on Hepatic Disorders, the latest volume in the Oxidative Stress in Basic Research and Clinical Practice series, provides a comprehensive look at liver topics. It is organized into four sections, each one thoroughly covering its topic and consisting of chapters written by recognized field leaders. Section One, covers basic principles including redox signaling, antioxidant defenses, nitric oxide, oxidative mechanisms in senescence and regeneration and the detection of oxidative stress. Section Two, explores Pathophysiology. It ranges from cell damage to fibrogenic response as broken out in chapters on hepatocellular injury, mitochondrial damage, unfolded protein response and autophagy, inflammation, ischemia-reperfusion injury and finally, fibrogenesis. Sections Three and Four cover specific diseases and cancer, respectively. Most of the chapters focus on diseases including acute failure, alcoholic disease, viral hepatitis, iron overload, autoimmune disease, Wilson's disease and more, while the chapters on cancer round out the book.
Part 1: Oxidative Stress: Basic Principles in the Liver Scenario.- Principles of Redox Signaling.- Oxidative Stress, Antioxidant Defenses and the Liver.- Oxidative Mechanisms in Liver Senescence and Regeneration.- Part 2: Oxidative Stress and Liver Pathophysiology: From Cell Damage and Death to Inflammatory and Fibrogenic Responses.- Oxidative Stress and Hepatocellular Injury.- Oxidative Stress and the Unfolded Protein Response in the Liver.- Oxidative Stress and Liver Inflammation.- Oxidative Stress and Liver Ischemia-Reperfusion Injury.- Oxidative Stress and Liver Fibrogenesis.- Part 3: Oxidative Stress in Specific Liver Disease Conditions.- Oxidative Stress in Acute Liver Failure.- Oxidative Stress in Alcoholic Liver Disease.- Oxidative Stress in Chronic Viral Hepatitis.- Oxidative Stress in Nonalcoholic Fatty Liver Disease.- Oxidative Stress in Non-autoimmune Biliary Diseases.- Oxidative Stress in Autoimmune Liver Diseases.- Oxidative Stress and Hepatic Iron Overload.- Oxidative Stress in the Central Nervous System Complications of Chronic Liver Failure.- Oxidative Stress and Liver Transplantation.- Antioxidant Approach to the Therapy of Chronic Liver Disease.- Part 4: Oxidative Stress and Liver Cancer.- Liver Cancer Classification.- Oxidative Stress Mechanisms in Hepatocarcinogenesis.- The Role of Oxidative Stress in Hepatocarcinogenesis.