Includes cutting-edge methods and protocols
Provides step-by-step detail essential for reproducible results
Contains key notes and implementation advice from the experts
This volume details state-of-art eQTL analysis, where interdisciplinary researchers are provided both theoretical and practical guidance to eQTL analysis and interpretation. Chapters guide readers through methods and tools for eQTL and QTL analysis and the usage of such analysis in various scenarios. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, eQTL Analysis: Methods and Protocols to ensure successful results in the further study of this vital field.
Part I: Foundations
1. Introductory Methods for eQTL Analyses
Conor Nodzak
2. Performing QTL and eQTL Analyses with the R-package GenomicTools
Daniel Fischer
3. eQTL Mapping using Tranillegalscription Factor Affinity
Elisa Mariella, Elena Grassi, and Paolo Provero
4. Identification and Quantification of Splicing Quantitative Trait Loci
Ankeeta Shah and Yang I. Li
5. Genome-wide Composite Interval Mapping (GCIM) of Expressional Quantitative Trait Loci in Backcross Population
Yuan-Ming Zhang
6. Combining eQTL and SNP Annotation Data to Identify Functional Noncoding SNPs in GWAS Trait-associated Regions
Stephen A. Ramsey, Zheng Liu, Yao Yao, and Benjamin Weeder
7. Statistical and Machine Learning Methods for eQTL Analysis
Junjie Chen and Conor Nodzak
8. Sparse Regression Models for Unraveling Group and Individual Associations in eQTL Mapping
Wei Cheng, Xiang Zhang, and Wei Wang
9. Exploring Bayesian Approaches to eQTL Mapping through
Probabilistic Programming
Dimitrios V. Vavoulis
10. High-order Association Mapping for Expression Quantitative Trait Loci
Huaizhen Qin, Weiwei Ouyang, and Jinying Zhao
11. Integration of Multi-omics Data for Expression Quantitative Trait Loci (eQTL) Analysis and eQTL Epistasis
Mingon Kang and Jean Gao
12. Sparse Partial Least Squares Methods for Joint Modular Pattern Discovery
Jinyu Chen and Shihua Zhang
Part II: Applications
13. Expression Quantitative Trait Loci (eQTL) Analysis in Cancer
Yaoming Liu, Youqiong Ye, Jing Gong, and Leng Han
14. QTL Analysis Beyond eQTLs
Jia Wen and Conor Nodzak
15. Quantitative Trait Loci (QTL) Mapping
Kara E. Powder
16. Expression Quantitative Trait Loci Analysis in Multiple Tissues
Gen Li
17. Tissue Specific eQTL in Zebrafish
Kimberly Dobrinski
This volume details state-of-art eQTL analysis, where interdisciplinary researchers are provided both theoretical and practical guidance to eQTL analysis and interpretation. Chapters guide readers through methods and tools for eQTL and QTL analysis and the usage of such analysis in various scenarios. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, eQTL Analysis: Methods and Protocols to ensure successful results in the further study of this vital field.
This volume details state-of-art eQTL analysis, where interdisciplinary researchers are provided both theoretical and practical guidance to eQTL analysis and interpretation. Chapters guide readers through methods and tools for eQTL and QTL analysis and the usage of such analysis in various scenarios. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, eQTL Analysis: Methods and Protocols to ensure successful results in the further study of this vital field.
Introductory Methods for eQTL Analyses.- Performing QTL and eQTL Analyses with the R-package GenomicTools.- eQTL Mapping using Tranillegalscription Factor Affinity.- Identification and Quantification of Splicing Quantitative Trait Loci.- Genome-wide Composite Interval Mapping (GCIM) of Expressional Quantitative Trait Loci in Backcross Population.- Combining eQTL and SNP Annotation Data to Identify Functional Noncoding SNPs in GWAS Trait-associated Regions.- Statistical and Machine Learning Methods for eQTL Analysis.- Sparse Regression Models for Unraveling Group and Individual Associations in eQTL Mapping.- Exploring Bayesian Approaches to eQTL Mapping through Probabilistic Programming.- High-order Association Mapping for Expression Quantitative Trait Loci.- Integration of Multi-omics Data for Expression Quantitative Trait Loci (eQTL) Analysis and eQTL Epistasis.- Sparse Partial Least Squares Methods for Joint Modular Pattern Discovery.- Expression Quantitative Trait Loci (eQTL) Analysis in Cancer.- QTL Analysis Beyond eQTLs.- Quantitative Trait Loci (QTL) Mapping.- Expression Quantitative Trait Loci Analysis in Multiple Tissues.- Tissue Specific eQTL in Zebrafish.
Inhaltsverzeichnis
Part I: Foundations
1. Introductory Methods for eQTL Analyses
Conor Nodzak
2. Performing QTL and eQTL Analyses with the R-package GenomicTools
Daniel Fischer
3. eQTL Mapping using Tranillegalscription Factor Affinity
Elisa Mariella, Elena Grassi, and Paolo Provero
4. Identification and Quantification of Splicing Quantitative Trait Loci
Ankeeta Shah and Yang I. Li
5. Genome-wide Composite Interval Mapping (GCIM) of Expressional Quantitative Trait Loci in Backcross Population
Yuan-Ming Zhang
6. Combining eQTL and SNP Annotation Data to Identify Functional Noncoding SNPs in GWAS Trait-associated Regions
Stephen A. Ramsey, Zheng Liu, Yao Yao, and Benjamin Weeder
7. Statistical and Machine Learning Methods for eQTL Analysis
Junjie Chen and Conor Nodzak
8. Sparse Regression Models for Unraveling Group and Individual Associations in eQTL Mapping
Wei Cheng, Xiang Zhang, and Wei Wang
9. Exploring Bayesian Approaches to eQTL Mapping through
Probabilistic Programming
Dimitrios V. Vavoulis
10. High-order Association Mapping for Expression Quantitative Trait Loci
Huaizhen Qin, Weiwei Ouyang, and Jinying Zhao
11. Integration of Multi-omics Data for Expression Quantitative Trait Loci (eQTL) Analysis and eQTL Epistasis
Mingon Kang and Jean Gao
12. Sparse Partial Least Squares Methods for Joint Modular Pattern Discovery
Jinyu Chen and Shihua Zhang
Part II: Applications
13. Expression Quantitative Trait Loci (eQTL) Analysis in Cancer
Yaoming Liu, Youqiong Ye, Jing Gong, and Leng Han
14. QTL Analysis Beyond eQTLs
Jia Wen and Conor Nodzak
15. Quantitative Trait Loci (QTL) Mapping
Kara E. Powder
16. Expression Quantitative Trait Loci Analysis in Multiple Tissues
Gen Li
17. Tissue Specific eQTL in Zebrafish
Kimberly Dobrinski
Klappentext
This volume details state-of-art eQTL analysis, where interdisciplinary researchers are provided both theoretical and practical guidance to eQTL analysis and interpretation. Chapters guide readers through methods and tools for eQTL and QTL analysis and the usage of such analysis in various scenarios. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.n nAuthoritative and cutting-edge, eQTL Analysis: Methods and Protocols to ensure successful results in the further study of this vital field.nnn
Includes cutting-edge methods and protocols
Provides step-by-step detail essential for reproducible results
Contains key notes and implementation advice from the experts
