High Quality Content by WIKIPEDIA articles! Cuyahoga County is a county located in the state of Ohio, United States. It is the most populous county in Ohio; as of the 2000 census, the population was 1,393,978. Its county seat is Cleveland. Cuyahoga County is part of Greater Cleveland, a metropolitan area, and Northeast Ohio, a thirteen-county region, joined together in economic development initiatives. The county is named after the Native American word (possibly Algonquian) Cuyahoga, which means "crooked river". The name is also assigned to the Cuyahoga River, which bisects the county. Former U.S. President James A. Garfield was born in what was Cuyahoga County's Orange Township.