Written by the leading names in pediatric oncology and hematology, Nathan and Oski's Hematology and Oncology of Infancy and Childhood offers you the essential tools you need to overcome the unique challenges and complexities of childhood cancers and hematologic disorders. Meticulously updated, this exciting full-color, two-volume set brings together the pathophysiology of disease with detailed clinical guidance to provide you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children.
- Form a definitive diagnosis and create the best treatment plans possible with comprehensive coverage of all pediatric cancers, including less-common tumors, as well as all hematologic disorders, including newly recognized ones.
- Develop a thorough, understanding of the underlying science of diseases through summaries of relevant pathophysiology balanced with clear, practical clinical guidance. Nathan and Oski's is the only comprehensive product on the market that relates pathophysiology in such depth to hematologic and oncologic diseases affecting children.
- Quickly and effortlessly access the key information you need with the help of a consistent organization from chapter to chapter and from volume to volume.
- Stay at the forefront of your field thanks to new and revised chapters covering topics such as paroxysmal nocturnal hemoglobinuria, lysosomal storage diseases, childhood genetic predisposition to cancer, and oncology informatics.
- Learn about the latest breakthroughs in diagnosis and management, making this the most complete guide in pediatric hematology and oncology.
- Discover the latest in focused molecularly targeted therapies derived from the exponential growth of knowledge about basic biology and genetics underlying the field.
- Rely on it anytime, anywhere! Access the full text, images, and more at Expert Consult.
Section I Neonatal Hematology
1. Anatomy and Physiology of Hematopoiesis
2. The Neonatal Erythrocyte and Its Disorders
3. Immune Hemolytic Disease
4. Neonatal Jaundice and Disorders of Bilirubin Metabolism
5. Hemostasis in the Newborn and Infant
Section II Bone Marrow Failure
6. Acquired Aplastic Anemia and Pure Red Cell Aplasia
7. Inherited Bone Marrow Failure Syndromes
8. Principles of Bone Marrow and Stem Cell Transplantation
Section III Disorders of Erythrocyte Production
9. Diagnostic Approach to the Anemic Patient
10. Megaloblastic Anemia
11. Disorders of Iron and Copper Metabolism, Sideroblastic Anemias and Lead Toxicity
12. Porphyrias
Section IV Hemolytic Anemias
13. Autoimmune Hemolytic Anemia
14. Paroxysmal Nocturnal Hemoglobinuria
15. Red Cell Membrane
16. Disorders of the Red Cell Membrane
17. Pyruvate Kinase Deficiency and Disorders of Glycolysis
18. Glucose-6-Phosphate Dehydrogenase Deficiency
19. Normal and Abnormal Hemoglobins
Section V Disorders of Hemoglobin
20. Sickle Cell Disease
21. Thalassemias
Section VI Phagocyte System
22. Phagocyte System and Disorders of Granulopoiesis and Granulocyte Function
Section VII Immune System
23. Immune Response
24. Primary Immunodeficiency Diseases
Section VIII Storage Diseases
25. Lysosomal Storage Diseases
Section IX Hemostasis
26. Platelets and the Vessel Wall
27. Blood Coagulation
28. Molecular Basis of Fibrinolysis
29. Approach to the Child with a Suspected Bleeding Disorder
30. Inherited Platelet Disorders
31. Hemophilia and von Willebrand Disease
32. Rare Hereditary Coagulation Factor Abnormalities
33. Inherited Disorders of Thrombosis and Fibrinolysis
34. Acquired Platelet Defects
35. Acquired Disorders of Hemostasis
Section X Supportive Therapy
36. Transfusion Medicine
Section XI Hematologic Manifestations of Systemic Diseases
37. Hematological Manifestations of Systemic Diseases
38. Hematology Manifestations of Systemic Diseases in Children of the Developing World
Section XII Biology of Cancer
39. Origins and Evolution of Pediatric Cancer
40. Epidemiology of Leukemia in Childhood
41. Informatics
42. Genetic Predisposition to Cancer
43. Genetic and Epigenetics of Childhood Cancers
44. Targeted Therapies in Oncology
45. Cytogenetic and Molecular Pathology of Pediatric Cancer
Section XIII Pediatric Cancer Therapeutics
46. Cancer Chemotherapy for Pediatric Patients
47. Immunotherapy of Cancer
48. Pediatric Radiation Oncology
48. Pediatric Surgical Oncology
Section XIV Hematologic Malignancy
50. Acute Lymphoblastic Leukemia
51. Pediatric Myeloid Leukemia, Myelodysplasia, and Myeloproliferative Disease
52. Infant Leukemias
53. Pediatric Lymphoma
Section XV Solid Tumors
54. Neuroblastoma
55. Pediatric Renal Tumors
56. Retinoblastoma
57. Tumors of the Brain and Spinal Cord
58. Hepatoblastoma and Other Liver Tumors in Children
59. Rhabdomyosarcoma
60. Nonrhabdomyosarcoma Soft Tissue Sarcomas and Other Soft Tissue Tumors
61. Ewing Sarcoma
62. Osteosarcoma
63. Pediatric Germ Cell Tumors
64. Histiocytoses
65. Rare Tumors of Childhood
66. Imaging in the Evaluation and Management of Childhood Cancer
Section XVI Supportive Care
67. Infectious Disease in the Pediatric Cancer Patient
68. Oncologic Emergencies
69. Nursing Care of Patients with Childhood Cancer
"This is a comprehensive, accurate, and up-to-date publication on the major issues in pediatric hematology/oncology. Both the book and the website are outstanding resources for any of the intended users -- students, practitioners, clinical and research investigators." ~Joseph Rosenthal, MD, City of Hope Doody Score: 4 stars
"This is an extremely useful, indispensable print and online resource on diseases of infants and children relating to the blood and cancer. It is a massive reference source that is well-researched, expertly organized and thoughtfully written." ~Nano Khilnani
David G. Nathan, M.D., was until recently the president of the Dana-Farber Institute, one of the world's leading centers for cancer research and treatment, and the physician-in-chief of the Children's Hospital in Boston. He is a Professor of Pediatrics and Medicine at Harvard Medical School.
Inhaltsverzeichnis
Section I Neonatal Hematology 1. Anatomy and Physiology of Hematopoiesis 2. The Neonatal Erythrocyte and Its Disorders 3. Immune Hemolytic Disease 4. Neonatal Jaundice and Disorders of Bilirubin Metabolism 5. Hemostasis in the Newborn and Infant Section II Bone Marrow Failure 6. Acquired Aplastic Anemia and Pure Red Cell Aplasia 7. Inherited Bone Marrow Failure Syndromes 8. Principles of Bone Marrow and Stem Cell Transplantation Section III Disorders of Erythrocyte Production 9. Diagnostic Approach to the Anemic Patient 10. Megaloblastic Anemia 11. Disorders of Iron and Copper Metabolism, Sideroblastic Anemias and Lead Toxicity 12. Porphyrias Section IV Hemolytic Anemias 13. Autoimmune Hemolytic Anemia 14. Paroxysmal Nocturnal Hemoglobinuria 15. Red Cell Membrane 16. Disorders of the Red Cell Membrane 17. Pyruvate Kinase Deficiency and Disorders of Glycolysis 18. Glucose-6-Phosphate Dehydrogenase Deficiency 19. Normal and Abnormal Hemoglobins Section V Disorders of Hemoglobin 20. Sickle Cell Disease 21. Thalassemias Section VI Phagocyte System 22. Phagocyte System and Disorders of Granulopoiesis and Granulocyte Function Section VII Immune System 23. Immune Response 24. Primary Immunodeficiency Diseases Section VIII Storage Diseases 25. Lysosomal Storage Diseases Section IX Hemostasis 26. Platelets and the Vessel Wall 27. Blood Coagulation 28. Molecular Basis of Fibrinolysis 29. Approach to the Child with a Suspected Bleeding Disorder 30. Inherited Platelet Disorders 31. Hemophilia and von Willebrand Disease 32. Rare Hereditary Coagulation Factor Abnormalities 33. Inherited Disorders of Thrombosis and Fibrinolysis 34. Acquired Platelet Defects 35. Acquired Disorders of Hemostasis Section X Supportive Therapy 36. Transfusion Medicine Section XI Hematologic Manifestations of Systemic Diseases 37. Hematological Manifestations of Systemic Diseases 38. Hematology Manifestations of Systemic Diseases in Children of the Developing World Section XII Biology of Cancer 39. Origins and Evolution of Pediatric Cancer 40. Epidemiology of Leukemia in Childhood 41. Informatics 42. Genetic Predisposition to Cancer 43. Genetic and Epigenetics of Childhood Cancers 44. Targeted Therapies in Oncology 45. Cytogenetic and Molecular Pathology of Pediatric Cancer Section XIII Pediatric Cancer Therapeutics 46. Cancer Chemotherapy for Pediatric Patients 47. Immunotherapy of Cancer 48. Pediatric Radiation Oncology 48. Pediatric Surgical Oncology Section XIV Hematologic Malignancy 50. Acute Lymphoblastic Leukemia 51. Pediatric Myeloid Leukemia, Myelodysplasia, and Myeloproliferative Disease 52. Infant Leukemias 53. Pediatric Lymphoma Section XV Solid Tumors 54. Neuroblastoma 55. Pediatric Renal Tumors 56. Retinoblastoma 57. Tumors of the Brain and Spinal Cord 58. Hepatoblastoma and Other Liver Tumors in Children 59. Rhabdomyosarcoma 60. Nonrhabdomyosarcoma Soft Tissue Sarcomas and Other Soft Tissue Tumors 61. Ewing Sarcoma 62. Osteosarcoma 63. Pediatric Germ Cell Tumors 64. Histiocytoses 65. Rare Tumors of Childhood 66. Imaging in the Evaluation and Management of Childhood Cancer Section XVI Supportive Care 67. Infectious Disease in the Pediatric Cancer Patient 68. Oncologic Emergencies 69. Nursing Care of Patients with Childhood Cancer 70. Palliative Care in Pediatric Oncology 71. Symptom Management in Children with Cancer 72. Childhood Cancer Survivorship 73. Psychosocial Care of the Child and Family 74. Ethical Considerations in Pediatric Oncology Clinical Trials Appendices: Reference Values in Infancy and Childhood
Klappentext
Written by the leading names in pediatric oncology and hematology, Nathan and Oski's Hematology and Oncology of Infancy and Childhood offers you the essential tools you need to overcome the unique challenges and complexities of childhood cancers and hematologic disorders. Meticulously updated, this exciting full-color, two-volume set brings together the pathophysiology of disease with detailed clinical guidance to provide you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children
